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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
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Digital Preservation
Contact us
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Table of Contents
DOIs
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Docs
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BIRC3 [cytosol]
Stable Identifier
R-CFA-50845
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A1E2V0
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Canis familiaris)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TRAF3 binds BAFFR:BAFF (Canis familiaris)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TRAFs bind RANK:RANKL (Canis familiaris)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Canis familiaris)
3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)
TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
NOD1/2 Signaling Pathway (Canis familiaris)
RIP2 is K63 polyubiquitinated (Canis familiaris)
RIP2 ubiquitin ligases [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
IKK complex recruitment mediated by RIP1 (Canis familiaris)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Canis familiaris)
RIP1 ubiqutin ligases [cytosol] (Canis familiaris)
c-IAP2:UBE2D [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
USP19 binds HIF1A,BIRC2,BIRC3 (Canis familiaris)
HIF1A,BIRC2,BIRC3 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
USP19:HIF1A,BIRC2,BIRC3 [cytosol] (Canis familiaris)
HIF1A,BIRC2,BIRC3 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
Regulation of necroptotic cell death (Canis familiaris)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Canis familiaris)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
BIRC3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A1E2V0
Reference Genes
BioGPS Gene:489433
ENSEMBL:ENSCAFG00040021208
KEGG:cfa:489433
Monarch:489433
NCBI Gene:489433
UCSC:A1E2V0
Reference Transcript
RefSeq:XM_005619513.2
RefSeq:XM_005619515.2
RefSeq:XM_005619514.2
RefSeq:NM_001080725.1
Other Identifiers
489433
Cfa.18376.1.S1_at
CfaAffx.23259.1.S1_s_at
GO:0003824
GO:0004842
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0016740
GO:0031398
GO:0042981
GO:0043226
GO:0060544
GO:0140096
Participates
as a member of
HIF1A,BIRC2,BIRC3 [cytosol] (Canis familiaris)
BIRC2,3,4 [cytosol] (Canis familiaris)
as a component of
c-IAP2:UBE2D [cytosol] (Canis familiaris)
as a candidate of
RIP2 ubiquitin ligases [cytosol] (Canis familiaris)
Other forms of this molecule
K63polyUb-BIRC3 [cytosol]
K48pUb-BIRC3 [cytosol]
Inferred From
BIRC3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001074194.1
,
XP_005619572.1
,
XP_005619571.1
,
XP_005619570.1
ENSEMBL
ENSCAFP00845001493
,
ENSCAFT00845001898
,
ENSCAFG00845001106
IntEnz
2.3.2.27
VGNC
53305
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