Reactome | BIRC2 [cytosol]

BIRC2 [cytosol]

Stable Identifier

R-CFA-50847

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

BIRC2, A0A8I3MDM0

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - TNFR2 non-canonical NF-kB pathway (Canis familiaris)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Canis familiaris)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)
        
        3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TRAF3 binds BAFFR:BAFF (Canis familiaris)
        
        3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TRAFs bind RANK:RANKL (Canis familiaris)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Canis familiaris)
        
        3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
    - TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)
      - TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
      - BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
    - cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)
      - TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
    - NOD1/2 Signaling Pathway (Canis familiaris)
      - RIP2 is K63 polyubiquitinated (Canis familiaris)
        
        RIP2 ubiquitin ligases [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        IKK complex recruitment mediated by RIP1 (Canis familiaris)
        
        K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Canis familiaris)
        
        RIP1 ubiqutin ligases [cytosol] (Canis familiaris)
        
        c-IAP1:UBE2D [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Death Receptor Signaling (Canis familiaris)
  - TNF signaling (Canis familiaris)
    - Regulation of TNFR1 signaling (Canis familiaris)
      - CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
        
        TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - CLIP3 and CYLD bind TNF signaling complex (Canis familiaris)
        
        CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - K63polyUb-RIPK1 is deubiquitinated (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
        
        CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Canis familiaris)
        
        K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Canis familiaris)
        
        RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
    - TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
      - BIRC(cIAP1/2) ubiquitinates RIPK1 (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
      - TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
        
        TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)
    - TNFR1-induced proapoptotic signaling (Canis familiaris)
      - TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
        
        BIRC2,3,4 [cytosol] (Canis familiaris)
        
        BIRC2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MDM0

Gene Names

BIRC2

Reference Genes

ENSEMBL:ENSCAFG00845001046.1

UCSC:A0A8I3MDM0 BIRC2

Reference Transcript

RefSeq:XM_005619507.2 BIRC2

Other Identifiers

479464

Cfa.19963.1.S1_s_at

Cfa.828.1.A1_at

CfaAffx.23248.1.S1_s_at

GO:0000209

GO:0001890

GO:0003713

GO:0003824

GO:0004842

GO:0005634

GO:0005737

GO:0006355

GO:0008270

GO:0009898

GO:0012501

GO:0016740

GO:0030163

GO:0031398

GO:0035631

GO:0042802

GO:0042981

GO:0043066

GO:0043067

GO:0043123

GO:0043130

GO:0043161

GO:0043226

GO:0045893

GO:0048856

GO:0051087

GO:0051726

GO:0060090

GO:0060544

GO:0060546

GO:0070266

GO:0071356

GO:0098770

GO:0140096

GO:0140110

GO:1901222

GO:1902443

GO:1902523

GO:1902524

GO:1902527

GO:1902916

GO:2000377

Participates

as a member of

as an input of

Caspase mediated cleavage of C-IAP1 (Canis familiaris)

as a component of

c-IAP1:UBE2D [cytosol] (Canis familiaris)

as a candidate of

RIP2 ubiquitin ligases [cytosol] (Canis familiaris)

Other forms of this molecule

BIRC2 [cytosol]

Inferred From

BIRC2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005619564.1

ENSEMBL

ENSCAFT00845001819, ENSCAFP00845001433, ENSCAFG00845001046

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