Reactome | CCNT1 [nucleoplasm]

CCNT1 [nucleoplasm]

Stable Identifier

R-CFA-51611

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

CCNT1, F6V6A9

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Nuclear Receptors (Canis familiaris)
  - ESR-mediated signaling (Canis familiaris)
    - Estrogen-dependent gene expression (Canis familiaris)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Canis familiaris)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Canis familiaris)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Canis familiaris)
        
        CCNT1 [nucleoplasm] (Canis familiaris)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Canis familiaris)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Canis familiaris)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Canis familiaris)
        
        CCNT1 [nucleoplasm] (Canis familiaris)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Canis familiaris)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Canis familiaris)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Canis familiaris)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Canis familiaris)
        
        CCNT1 [nucleoplasm] (Canis familiaris)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Canis familiaris)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Canis familiaris)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Canis familiaris)
        
        CCNT1 [nucleoplasm] (Canis familiaris)
- Signaling by TGFB family members (Canis familiaris)
  - Signaling by TGF-beta Receptor Complex (Canis familiaris)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Canis familiaris)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Canis familiaris)
        
        P-TEFb complex [nucleoplasm] (Canis familiaris)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Canis familiaris)
        
        CCNT1 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:F6V6A9

Gene Names

CCNT1

Reference Genes

BioGPS Gene:486564 CCNT1

ENSEMBL:ENSCAFG00000008923

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000008923 CCNT1

Monarch:486564 CCNT1

NCBI Gene:486564 CCNT1

Reference Transcript

RefSeq:XM_543690.6 CCNT1

Other Identifiers

486564

CfaAffx.14094.1.S1_s_at

GO:0000079

GO:0000976

GO:0003674

GO:0003677

GO:0003682

GO:0003723

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006351

GO:0006357

GO:0006397

GO:0006464

GO:0006468

GO:0007049

GO:0008024

GO:0008134

GO:0008150

GO:0009058

GO:0016538

GO:0017069

GO:0019899

GO:0019901

GO:0030234

GO:0032786

GO:0032991

GO:0034641

GO:0042025

GO:0043226

GO:0045737

GO:0045944

GO:0061575

GO:0070063

GO:0097322

GO:1900364

Participant Of

hasComponent

P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm]

hasMember

CCNT1,CCNT2,CCNK [nucleoplasm]

Inferred From

CCNT1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_543690.2

OpenTargets

ENSG00000129315

Ensembl

ENSCAFG00000008923, ENSCAFP00000013117, ENSCAFT00000014180

VGNC

38906

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