Reactome | FEN1 [nucleoplasm]

FEN1 [nucleoplasm]

Stable Identifier

R-CFA-54745

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

FEN1, A0A8I3NJ50

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle, Mitotic (Canis familiaris)
  - S Phase (Canis familiaris)
    - Synthesis of DNA (Canis familiaris)
      - DNA strand elongation (Canis familiaris)
        
        Lagging Strand Synthesis (Canis familiaris)
        
        Processive synthesis on the lagging strand (Canis familiaris)
        
        Removal of the Flap Intermediate (Canis familiaris)
        
        Removal of remaining Flap (Canis familiaris)
        
        FEN1 [nucleoplasm] (Canis familiaris)
- Chromosome Maintenance (Canis familiaris)
  - Telomere Maintenance (Canis familiaris)
    - Extension of Telomeres (Canis familiaris)
      - Telomere C-strand (Lagging Strand) Synthesis (Canis familiaris)
        
        Processive synthesis on the C-strand of the telomere (Canis familiaris)
        
        Removal of the Flap Intermediate from the C-strand (Canis familiaris)
        
        Removal of remaining Flap from the C-strand (Canis familiaris)
        
        FEN1 [nucleoplasm] (Canis familiaris)

DNA Replication (Canis familiaris)

- Synthesis of DNA (Canis familiaris)
  - DNA strand elongation (Canis familiaris)
    - Lagging Strand Synthesis (Canis familiaris)
      - Processive synthesis on the lagging strand (Canis familiaris)
        
        Removal of the Flap Intermediate (Canis familiaris)
        
        Removal of remaining Flap (Canis familiaris)
        
        FEN1 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NJ50

Gene Names

FEN1

Reference Genes

BioGPS Gene:476063 FEN1

ENSEMBL:ENSCAFG00845011341.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011341.1 FEN1

KEGG Gene (Canis lupus familiaris):476063 FEN1

Monarch:476063 FEN1

NCBI Gene:476063 FEN1

Reference Transcript

Other Identifiers

476063

Cfa.1780.1.S1_at

CfaAffx.24613.1.S1_s_at

GO:0000781

GO:0003677

GO:0003824

GO:0004518

GO:0004523

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005739

GO:0006260

GO:0008409

GO:0016787

GO:0016788

GO:0017108

GO:0032991

GO:0043137

GO:0043226

GO:0045876

GO:0048256

GO:0090305

GO:0140097

GO:0140098

Participates

as an input of

as a component of

as an output of

FEN1 cleaves displaced ssDNA flaps during MMEJ (Canis familiaris)

Inferred From

FEN1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_533271.1, XP_005631709.1

OpenTargets

ENSG00000168496

Ensembl

ENSCAFP00845015746, ENSCAFG00845011341, ENSCAFT00845020094