Reactome | GNAI2 [plasma membrane]

GNAI2 [plasma membrane]

Stable Identifier

R-CFA-55435

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

P38400

Locations in the PathwayBrowser

Expand all

Hemostasis (Canis familiaris)

- Platelet activation, signaling and aggregation (Canis familiaris)
  - Signal amplification (Canis familiaris)
    - ADP signalling through P2Y purinoceptor 12 (Canis familiaris)
      - Activated P2Y purinoceptor 12 binds G-protein Gi (Canis familiaris)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
      - Dissociation of the P2Y purinoceptor 12:Gi complex (Canis familiaris)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
      - Gi activation by P2Y purinoceptor 12 (Canis familiaris)
        
        ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)

Neuronal System (Canis familiaris)

- Transmission across Chemical Synapses (Canis familiaris)
  - Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
    - GABA receptor activation (Canis familiaris)
      - GABA B receptor activation (Canis familiaris)
        
        Activation of GABAB receptors (Canis familiaris)
        
        Adenylate cyclase inhibitory pathway (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        Dissociation of the Gi alpha:G olf complex (Canis familiaris)
        
        (Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GDP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Canis familiaris)
        
        (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)
        
        G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Canis familiaris)
        
        G alpha (i): GTP [plasma membrane] (Canis familiaris)
        
        G alpha (i) [plasma membrane] (Canis familiaris)
        
        GNAI2 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:P38400

Reference Genes

BioGPS Gene:442957

ENSEMBL:ENSCAFG00845022609

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000010740.5

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030012013.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040016016.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805024221

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845022609.1

KEGG Gene (Canis lupus familiaris):442957

Monarch:442957

NCBI Gene:442957

Reference Transcript

RefSeq:NM_001003364.1

Other Identifiers

442957

Cfa.16783.1.A1_s_at

Cfa.3918.1.S1_at

GO:0003824

GO:0003924

GO:0005525

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0007165

GO:0007186

GO:0007188

GO:0007193

GO:0007213

GO:0008283

GO:0008284

GO:0016787

GO:0019001

GO:0023052

GO:0030425

GO:0030496

GO:0031410

GO:0031683

GO:0043226

GO:0044297

GO:0051301

GO:0098992

Participates

as a candidate of

G alpha (i,o) (candidates) [plasma membrane] (Canis familiaris)

as a member of

G alpha (i) [plasma membrane] (Canis familiaris)

Inferred From

GNAI2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001003364.1

Ensembl

ENSCAFG00845022609, ENSCAFP00845031303, ENSCAFT00845039975

VGNC

41302

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