Reactome | TUBB4A [axonemal microtubule]

TUBB4A [axonemal microtubule]

Stable Identifier

R-CFA-5610435

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

axonemal microtubule

Synonyms

TUBB4A, A0A8I3NFI7

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Canis familiaris)

- Cilium Assembly (Canis familiaris)
  - Intraflagellar transport (Canis familiaris)
    - Anterograde IFT (Canis familiaris)
      - anterograde IFT trains [ciliary tip] (Canis familiaris)
        
        active kinesin-2 motors [ciliary tip] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
      - anterograde IFT trains [cilium] (Canis familiaris)
        
        active kinesin-2 motors [cilium] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
    - Assembly of the anterograde IFT train (Canis familiaris)
      - active kinesin-2 motors [cilium] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
      - anterograde IFT trains [cilium] (Canis familiaris)
        
        active kinesin-2 motors [cilium] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
    - Assembly of the retrograde IFT train (Canis familiaris)
      - active dynein-2 motors [ciliary tip] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
      - retrograde IFT trains [ciliary tip] (Canis familiaris)
        
        active dynein-2 motors [ciliary tip] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
    - Retrograde IFT (Canis familiaris)
      - retrograde IFT trains [ciliary tip] (Canis familiaris)
        
        active dynein-2 motors [ciliary tip] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
      - retrograde IFT trains [cilium] (Canis familiaris)
        
        active dynein-2 motors [cilium] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
    - The anterograde IFT train dissociates (Canis familiaris)
      - acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
      - anterograde IFT trains [ciliary tip] (Canis familiaris)
        
        active kinesin-2 motors [ciliary tip] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
    - The retrograde IFT train dissociates (Canis familiaris)
      - acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)
      - retrograde IFT trains [cilium] (Canis familiaris)
        
        active dynein-2 motors [cilium] (Canis familiaris)
        
        acetylated microtubule [axonemal microtubule] (Canis familiaris)
        
        Ac K40 alpha tubulin-beta tubulin dimer [axonemal microtubule] (Canis familiaris)
        
        beta tubulin:GDP [axonemal microtubule] (Canis familiaris)
        
        beta tubulin [axonemal microtubule] (Canis familiaris)
        
        TUBB4A [axonemal microtubule] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NFI7

Gene Names

TUBB4A

Reference Genes

BioGPS Gene:100855815 TUBB4A

ENSEMBL:ENSCAFG00845010611.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845010611.1 TUBB4A

KEGG Gene (Canis lupus familiaris):100855815 TUBB4A

Monarch:100855815 TUBB4A

NCBI Gene:100855815 TUBB4A

Reference Transcript

RefSeq:XM_005632973.2 TUBB4A

Other Identifiers

100855815

Cfa.15997.1.S1_at

GO:0000166

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005509

GO:0005525

GO:0005737

GO:0005856

GO:0005874

GO:0005929

GO:0005930

GO:0007010

GO:0007017

GO:0015630

GO:0016787

GO:0031115

GO:0033269

GO:0042995

GO:0043025

GO:0043209

GO:0043226

GO:0045171

GO:0065003

GO:0072686

Participates

as a candidate of

beta tubulin [axonemal microtubule] (Canis familiaris)

Other forms of this molecule

TUBB4A [cytosol]

Inferred From

TUBB4A [axonemal microtubule] (Homo sapiens)

Cross References

RefSeq

XP_005633030.1

OpenTargets

ENSG00000104833

Ensembl

ENSCAFP00845014603, ENSCAFG00845010611, ENSCAFT00845018708

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