Reactome | RMI1 [nucleoplasm]

RMI1 [nucleoplasm]

Stable Identifier

R-CFA-5685949

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

RMI1, E2RK78

Locations in the PathwayBrowser

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DNA Repair (Canis familiaris)

- DNA Double-Strand Break Repair (Canis familiaris)
  - Homology Directed Repair (Canis familiaris)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
      - HDR through Homologous Recombination (HRR) (Canis familiaris)
        
        D-loop extension by DNA polymerases (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Homologous DNA Pairing and Strand Exchange (Canis familiaris)
        
        CX3 complex binds D-loop structures (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        D-loop formation mediated by PALB2, BRCA2 and RAD51 (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Canis familiaris)
        
        BCDX2 complex stabilizes RAD51 filament (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Resolution of D-Loop Structures (Canis familiaris)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Canis familiaris)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Canis familiaris)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Ligation of DNA and formation of Holliday structures following repair synthesis (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        MUS81:EME1,EME2 cleaves D-loop (Canis familiaris)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
        
        Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        SPIDR binds BLM:TOP3A:RMI1:RMI2 (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2:SPIDR [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
      - HDR through Single Strand Annealing (SSA) (Canis familiaris)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Canis familiaris)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Canis familiaris)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
      - Processing of DNA double-strand break ends (Canis familiaris)
        
        ATR activation at DNA DSBs (Canis familiaris)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        ATR phosphorylates RPA2 (Canis familiaris)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Activation of CHEK1 at resected DNA DSBs (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Association of RPA complexes with ssDNA at resected DNA DSBs (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Binding of ATR:ATRIP to RPA at resected DNA DSBs (Canis familiaris)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        CHEK1 is recruited to resected DNA DSBs (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Canis familiaris)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)
        
        3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)
        
        3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
        
        EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
        
        DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
        
        RMI1 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RK78

Gene Names

RMI1

Reference Genes

ENSEMBL:ENSCAFG00000001390

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000001390 RMI1

Other Identifiers

100684392

CfaAffx.2964.1.S1_at

CfaAffx.2966.1.S1_s_at

GO:0000003

GO:0000166

GO:0000712

GO:0000724

GO:0002021

GO:0002023

GO:0003674

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006259

GO:0006950

GO:0007049

GO:0007059

GO:0008150

GO:0009749

GO:0016604

GO:0031422

GO:0032991

GO:0034641

GO:0035264

GO:0040007

GO:0042592

GO:0042593

GO:0043226

Participant Of

hasComponent

BLM:TOP3A:RMI1:RMI2 [nucleoplasm]

Inferred From

RMI1 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000178966

Ensembl

ENSCAFT00000002145, ENSCAFG00000001390, ENSCAFP00000001985

VGNC

45608

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