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RMI2 [nucleoplasm]
Stable Identifier
R-CFA-5685951
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
RMI2, A0A8I3RX89
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
G2/M DNA damage checkpoint (Canis familiaris)
ATR phosphorylates TP53 (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
DNA Repair (Canis familiaris)
DNA Double-Strand Break Repair (Canis familiaris)
Homology Directed Repair (Canis familiaris)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
HDR through Homologous Recombination (HRR) (Canis familiaris)
D-loop extension by DNA polymerases (Canis familiaris)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Homologous DNA Pairing and Strand Exchange (Canis familiaris)
CX3 complex binds D-loop structures (Canis familiaris)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
D-loop formation mediated by PALB2, BRCA2 and RAD51 (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Presynaptic phase of homologous DNA pairing and strand exchange (Canis familiaris)
BCDX2 complex stabilizes RAD51 filament (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 complex [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Resolution of D-Loop Structures (Canis familiaris)
Resolution of D-loop Structures through Holliday Junction Intermediates (Canis familiaris)
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Canis familiaris)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Ligation of DNA and formation of Holliday structures following repair synthesis (Canis familiaris)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
MUS81:EME1,EME2 cleaves D-loop (Canis familiaris)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Canis familiaris)
Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
HDR through Single Strand Annealing (SSA) (Canis familiaris)
Association of RAD51 with RAD52:DNA double-strand break ends (Canis familiaris)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Association of RAD52 with the RPA complex at resected DNA DSBs (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
ERCC1:XPF cleaves flaps generated by SSA (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
RAD52 promotes single strand annealing at resected DNA DSBs (Canis familiaris)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Processing of DNA double-strand break ends (Canis familiaris)
ATR activation at DNA DSBs (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
ATR phosphorylates RPA2 (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Activation of CHEK1 at resected DNA DSBs (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Association of RPA complexes with ssDNA at resected DNA DSBs (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Binding of ATR:ATRIP to RPA at resected DNA DSBs (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
CHEK1 is recruited to resected DNA DSBs (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment (Canis familiaris)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Long-range resection of DNA DSBs by EXO1 or DNA2 (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Activity through Phosphorylation (Canis familiaris)
ATR phosphorylates TP53 (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Canis familiaris)
EXO1,DNA2:BLM,WRN [nucleoplasm] (Canis familiaris)
DNA2:BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
RMI2 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3RX89
Gene Names
RMI2
Reference Genes
BioGPS Gene:609907 RMI2
ENSEMBL:ENSCAFG00845012909.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845012909.1 RMI2
KEGG Gene (Canis lupus familiaris):609907 RMI2
Monarch:609907 RMI2
NCBI Gene:609907 RMI2
Reference Transcript
RefSeq:XM_847255.4 RMI2
Other Identifiers
609907
CfaAffx.28874.1.S1_at
GO:0000724
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006281
GO:0006310
GO:0007059
GO:0016607
GO:0031422
GO:0033045
GO:0043226
GO:0071139
Participates
as a component of
BLM:TOP3A:RMI1:RMI2 [nucleoplasm] (Canis familiaris)
Inferred From
RMI2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_852348.2
OpenTargets
ENSG00000175643
Ensembl
ENSCAFG00845012909
,
ENSCAFP00845017984
,
ENSCAFT00845022941
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