Reactome | phospho-RAD52 [nucleoplasm]

phospho-RAD52 [nucleoplasm]

Stable Identifier

R-CFA-5686588

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

p-Y104-RAD52, A0A8I3Q232

Locations in the PathwayBrowser

Expand all

DNA Repair (Canis familiaris)

- DNA Double-Strand Break Repair (Canis familiaris)
  - Homology Directed Repair (Canis familiaris)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Canis familiaris)
      - HDR through Single Strand Annealing (SSA) (Canis familiaris)
        
        ABL1 phosphorylates RAD52 (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Canis familiaris)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)
        
        ERCC1:XPF cleaves flaps generated by SSA (Canis familiaris)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Canis familiaris)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)
        
        p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)
        
        phospho-RAD52 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q232

Gene Names

RAD52

Reference Genes

BioGPS Gene:477729 RAD52

ENSEMBL:ENSCAFG00845028934.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845028934.1 RAD52

KEGG Gene (Canis lupus familiaris):477729 RAD52

Monarch:477729 RAD52

NCBI Gene:477729 RAD52

Reference Transcript

Other Identifiers

477729

Cfa.17160.1.S1_at

CfaAffx.24254.1.S1_s_at

CfaAffx.24255.1.S1_s_at

GO:0000724

GO:0000730

GO:0003677

GO:0003697

GO:0005634

GO:0006281

GO:0006310

GO:0010792

GO:0032991

GO:0032993

GO:0034599

GO:0042802

GO:0043226

GO:0045002

GO:0065003

GO:2000819

Participates

as a component of

p-Y104-RAD52 heptamer [nucleoplasm] (Canis familiaris)

Other forms of this molecule

RAD52 [nucleoplasm]

Inferred From

p-Y104-RAD52 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 104 (in Homo sapiens)

Coordinate

104

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_005637410.1, XP_013963823.1, XP_005637408.1, XP_013963824.1, XP_005637406.1, XP_005637409.1, XP_005637407.1, XP_005637412.1

OpenTargets

ENSG00000002016

Ensembl

ENSCAFP00845040115, ENSCAFG00845028934, ENSCAFT00845051157

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