Reactome | GTF2H5 [nucleoplasm]

GTF2H5 [nucleoplasm]

Stable Identifier

R-CFA-5688446

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

GTF2H5, A0A8I3MY59

Locations in the PathwayBrowser

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DNA Repair (Canis familiaris)

- Nucleotide Excision Repair (Canis familiaris)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Canis familiaris)
    - Dual Incision in GG-NER (Canis familiaris)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Canis familiaris)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Canis familiaris)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Canis familiaris)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Canis familiaris)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
    - Formation of Incision Complex in GG-NER (Canis familiaris)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Canis familiaris)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Canis familiaris)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - CHD1L is recruited to GG-NER site (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - Formation of the pre-incision complex in GG-NER (Canis familiaris)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Canis familiaris)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - RNF111 ubiquitinates SUMOylated XPC (Canis familiaris)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - Recruitment of XPA and release of CAK (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        TFIIH Core [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - TFIIH binds GG-NER site to form a verification complex (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Canis familiaris)
    - Dual incision in TC-NER (Canis familiaris)
      - 3' incision by ERCC5 (XPG) in TC-NER (Canis familiaris)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Canis familiaris)
        
        TC-NER incision complex [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Canis familiaris)
        
        TC-NER incision complex [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Canis familiaris)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
        
        TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - ERCC5 and RPA bind TC-NER site (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
    - Formation of TC-NER Pre-Incision Complex (Canis familiaris)
      - Active RNA Pol II complex transcribes lesion-containing DNA template (Canis familiaris)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - Assembly of the pre-incision complex in TC-NER (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - ERCC6 binds stalled RNA Pol II (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - ERCC8 (CSA) binds stalled RNA Pol II (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - RNA Pol II initiates transcription from damaged DNA template (Canis familiaris)
        
        Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - UVSSA:USP7 deubiquitinates ERCC6 (Canis familiaris)
        
        TC-NER pre-incision complex [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Canis familiaris)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Canis familiaris)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Canis familiaris)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Canis familiaris)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Canis familiaris)
        
        TFIIH [nucleoplasm] (Canis familiaris)
        
        GTF2H5 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MY59

Gene Names

GTF2H5

Reference Genes

BioGPS Gene:612182 GTF2H5

ENSEMBL:ENSCAFG00845001194.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845001194.1 GTF2H5

KEGG Gene (Canis lupus familiaris):612182 GTF2H5

Monarch:612182 GTF2H5

NCBI Gene:612182 GTF2H5

Reference Transcript

Other Identifiers

612182

Cfa.16406.1.S1_at

CfaAffx.1896.1.S1_s_at

GO:0000439

GO:0000462

GO:0005634

GO:0005654

GO:0005669

GO:0005730

GO:0006281

GO:0006289

GO:0006294

GO:0006351

GO:0006362

GO:0006367

GO:0042254

GO:0043226

GO:0065003

GO:0071480

Participates

as a component of

Inferred From

GTF2H5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_855012.1, XP_005615600.1

OpenTargets

ENSG00000272047

Ensembl

ENSCAFG00845001194, ENSCAFP00845001604, ENSCAFT00845002049

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