Reactome | CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane]

CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-CFA-5689730

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

(Glc)3(GlcNAc)2(Man)9-CTSZ, A0A8I3NT46

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPII-mediated vesicle transport (Canis familiaris)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - ER to Golgi Anterograde Transport (Canis familiaris)
    - COPII-mediated vesicle transport (Canis familiaris)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        glycosylated LMAN cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NT46

Gene Names

CTSZ

Reference Genes

ENSEMBL:ENSCAFG00845014050.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845014050.1 CTSZ

Other Identifiers

611983

Cfa.12490.1.A1_at

CfaAffx.18934.1.S1_at

GO:0003824

GO:0004180

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005783

GO:0005938

GO:0006508

GO:0008234

GO:0010757

GO:0016787

GO:0031410

GO:0043226

GO:0043231

GO:0048856

GO:0051604

GO:0060441

GO:0140096

Participates

as a member of

glycosylated LMAN cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

Other forms of this molecule

CTSZ [Golgi lumen]

CTSZ [lysosomal lumen]

CTSZ [plasma membrane]

CTSZ [specific granule lumen]

CTSZ [extracellular region]

CTSZ [ficolin-1-rich granule lumen]

CTSZ [COPII-coated ER to Golgi transport vesicle]

CTSZ [endoplasmic reticulum lumen]

Inferred From

(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position

Modification

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Cross References

OpenTargets

ENSG00000101160

Ensembl

ENSCAFP00845019802, ENSCAFG00845014050, ENSCAFT00845025181