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IRS2 [cytosol]
Stable Identifier
R-CFA-57528
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
IRS2, A0A8I3S0I1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
RET signaling (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes:RET interactors [plasma membrane] (Canis familiaris)
RET interactors [cytosol] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
RET interactors [cytosol] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-7 signaling (Canis familiaris)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Canis familiaris)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Canis familiaris)
IRS1,2 [cytosol] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
IRS1,2 [cytosol] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Erythropoietin (Canis familiaris)
EPOR binds EPOR agonists (Canis familiaris)
EPOR agonists:EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K bound to EPOR [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
Erythropoietin activates RAS (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS activation (Canis familiaris)
Binding of IRS to insulin receptor (Canis familiaris)
IRS1,2 [cytosol] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
IRS1,2 [cytosol] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
Phosphorylation of IRS (Canis familiaris)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
IRS1,2 [cytosol] (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Canis familiaris)
IRS2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3S0I1
Gene Names
IRS2
Reference Genes
ENSEMBL:ENSCAFG00845018486.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018486.1 IRS2
Other Identifiers
485548
CfaAffx.10077.1.S1_at
GO:0002053
GO:0002376
GO:0002903
GO:0005068
GO:0005158
GO:0005829
GO:0005886
GO:0005975
GO:0006091
GO:0006629
GO:0007165
GO:0007420
GO:0008283
GO:0008284
GO:0008286
GO:0009749
GO:0010631
GO:0010634
GO:0010748
GO:0010907
GO:0012501
GO:0016477
GO:0019901
GO:0023052
GO:0030674
GO:0030879
GO:0030890
GO:0032000
GO:0032024
GO:0032869
GO:0043548
GO:0044342
GO:0045725
GO:0046326
GO:0048856
GO:0048870
GO:0051897
GO:0055085
GO:0060090
GO:0141038
GO:1904692
Participates
as a member of
RET interactors [cytosol] (Canis familiaris)
IRS1,2 [cytosol] (Canis familiaris)
as a component of
EPOR:JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Canis familiaris)
as an input of
IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 (Canis familiaris)
Other forms of this molecule
IRS2 [plasma membrane]
phospho-IRS2 [cytosol]
phospho-IRS2 [plasma membrane]
Inferred From
IRS2 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000185950
Ensembl
ENSCAFG00845018486
,
ENSCAFT00845032706
,
ENSCAFP00845025586
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