Reactome | FAAP20 [nucleoplasm]

FAAP20 [nucleoplasm]

Stable Identifier

R-CFA-6783321

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

J9P3L1

Locations in the PathwayBrowser

Expand all

DNA Repair (Canis familiaris)

- Fanconi Anemia Pathway (Canis familiaris)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Canis familiaris)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Canis familiaris)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        p-FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
  - DNA nucleases bind monoubiquitinated ID2 complex (Canis familiaris)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        p-FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Canis familiaris)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        p-FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Canis familiaris)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Canis familiaris)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        p-FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Canis familiaris)
      - FA core complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
  - FANCD2 deubiquitination by USP1:WDR48 (Canis familiaris)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        p-FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
      - p-FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Canis familiaris)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
      - FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
  - Monoubiquitination of FANCD2:FANCI (Canis familiaris)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        p-FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        p-FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
  - POLN binds ICL-DNA (Canis familiaris)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Canis familiaris)
      - FA core complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Canis familiaris)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Canis familiaris)
        
        FA core complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Canis familiaris)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Canis familiaris)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Canis familiaris)
        
        FA Core Complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
  - Translesion synthesis across unhooked ICL by POLN (Canis familiaris)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Canis familiaris)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Canis familiaris)
        
        FA core complex [nucleoplasm] (Canis familiaris)
        
        FAAP20 [nucleoplasm] (Canis familiaris)
    - p-FA Core Complex [nucleoplasm] (Canis familiaris)
      - FAAP20 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:J9P3L1

Reference Genes

ENSEMBL:ENSCAFG00000028473

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000028473

Other Identifiers

GO:0003674

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006950

GO:0006974

GO:0008150

GO:0032991

GO:0043226

GO:0043240

GO:0070530

Participant Of

hasComponent

Inferred From

FAAP20 [nucleoplasm] (Homo sapiens)

Cross References

Ensembl

ENSCAFT00000047565, ENSCAFP00000040140, ENSCAFG00000028473

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