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phospho-TYK2 [cytosol]
Stable Identifier
R-CFA-6784366
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-Y-TYK2, A0A8I3S6B0
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-10 signaling (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
JAK1,TYK2 phosphorylate JAK1,TYK2 (Canis familiaris)
IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Canis familiaris)
IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Canis familiaris)
IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
Interleukin-12 family signaling (Canis familiaris)
Interleukin-12 signaling (Canis familiaris)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12RB1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12RB1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12RB1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12RB1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12RB1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Canis familiaris)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Canis familiaris)
IL12RB1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
Interleukin-4 and Interleukin-13 signaling (Canis familiaris)
IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
STAT1,STAT3,STAT6 bind IL13:IL13R type II (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
STAT1,STAT3,STAT6 phosphorylation (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with STAT1,STAT3,STAT6 [plasma membrane] (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
p-Y1007-JAK2,p-Y-TYK2 [cytosol] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
p-Y-STATs dissociate (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13 receptor type II with phosphorylated STAT1,STAT3,STAT6 [plasma membrane] (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
IL13-bound tyrosine-phosphorylated IL13R type II [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2:p-Y-IL4R:p-Y1007-JAK2 [plasma membrane] (Canis familiaris)
IL13:p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
phospho-TYK2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3S6B0
Gene Names
TYK2
Reference Genes
ENSEMBL:ENSCAFG00845027438.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845027438.1 TYK2
Other Identifiers
476714
CfaAffx.27300.1.S1_at
CfaAffx.27321.1.S1_s_at
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005131
GO:0005524
GO:0005634
GO:0005737
GO:0005856
GO:0006468
GO:0007155
GO:0007259
GO:0016020
GO:0016740
GO:0023052
GO:0032729
GO:0032819
GO:0035556
GO:0035722
GO:0036211
GO:0042102
GO:0043226
GO:0046427
GO:0051142
GO:0060333
GO:0060337
GO:0098542
GO:0140096
GO:1900182
Participates
as a component of
IL12RB1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
p-Y-IL13RA1:p-Y-TYK2 [plasma membrane] (Canis familiaris)
IL10RB:p-Y-TYK2 [plasma membrane] (Canis familiaris)
as a member of
p-Y1007-JAK2,p-Y-TYK2 [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-TYK2 [cytosol]
TYK2 [cytosol]
phospho-TYK2 [cytosol]
phospho-TYK2 [cytosol]
Inferred From
p-Y-TYK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000105397
Ensembl
ENSCAFP00845037934
,
ENSCAFT00845048349
,
ENSCAFG00845027438
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