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phospho-MDM2 [nucleoplasm]
Stable Identifier
R-CFA-6795669
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
PolyUb,p-S166,S188-MDM2, P56950
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Dependent G1/S DNA damage checkpoint (Canis familiaris)
p53-Dependent G1 DNA Damage Response (Canis familiaris)
Stabilization of p53 (Canis familiaris)
MDM2 ubiquitinates phosphorylated MDM4 (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional Regulation by TP53 (Canis familiaris)
Regulation of TP53 Activity (Canis familiaris)
Regulation of TP53 Expression and Degradation (Canis familiaris)
Regulation of TP53 Degradation (Canis familiaris)
DAXX binds Ub-MDM2 and USP7 (Canis familiaris)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:(PolyUb,p-S166,S188-MDM2, PolyUb,p-S342,S367,S403-MDM4) [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2 homodimer [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:(PolyUb,p-S166,S188-MDM2, PolyUb,p-S342,S367,S403-MDM4) [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2 homodimer [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
MDM2 homodimers auto-ubiquitinate (Canis familiaris)
PolyUb,p-S166,S188-MDM2 homodimer [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
MDM2 ubiquitinates phosphorylated MDM4 (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
USP2 binds the heterodimer of MDM2 and MDM4 (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)
USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
USP7 deubiquitinates MDM2 (Canis familiaris)
DAXX:(PolyUb,p-S166,S188-MDM2):USP7 [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:(PolyUb,p-S166,S188-MDM2, PolyUb,p-S342,S367,S403-MDM4) [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2 homodimer [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
USP2 deubiquitinates MDM2,MDM4 (Canis familiaris)
USP2:PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
phospho-MDM2 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:P56950
Gene Names
MDM2
Reference Genes
BioGPS Gene:403693 MDM2
ENSEMBL:ENSCAFG00030007887
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000000418.5 MDM2
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030007887.1 MDM2
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845016387.1 MDM2
Monarch:403693 MDM2
NCBI Gene:403693 MDM2
Reference Transcript
RefSeq:NM_001003103.2 MDM2
Other Identifiers
403693
481154
Cfa.702.2.S1_at
CfaAffx.1587.1.S1_at
CfaAffx.1587.1.S1_s_at
GO:0002039
GO:0003723
GO:0003824
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006915
GO:0008097
GO:0010468
GO:0012501
GO:0016567
GO:0016740
GO:0036211
GO:0042802
GO:0043021
GO:0043066
GO:0043130
GO:0043226
GO:0046872
GO:0051726
GO:0061630
GO:0065008
GO:0140096
Participates
as a component of
PolyUb,p-S166,S188-MDM2 homodimer [nucleoplasm] (Canis familiaris)
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (Canis familiaris)
Other forms of this molecule
MDM2 [nucleoplasm]
phospho-MDM2 [nucleoplasm]
MDM2 [plasma membrane]
MDM2 [endocytic vesicle membrane]
phospho-MDM2 [nucleoplasm]
MDM2 [nucleoplasm]
MDM2 [cytosol]
phospho-MDM2 [cytosol]
phospho-MDM2 [nucleoplasm]
Inferred From
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 166 (in Homo sapiens)
Coordinate
166
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 188 (in Homo sapiens)
Coordinate
188
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position
Modification
PolyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001003103.1
OpenTargets
ENSG00000135679
IntEnz
2.3.2.27
Ensembl
ENSCAFT00845029644
,
ENSCAFP00845023282
,
ENSCAFG00845016387
VGNC
43106
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