Reactome | ICE1 [nucleoplasm]

ICE1 [nucleoplasm]

Stable Identifier

R-CFA-6807433

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

ICE1, A0A8I3S4C3

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - RNA polymerase II transcribes snRNA genes (Canis familiaris)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE1 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE1 [nucleoplasm] (Canis familiaris)
    - Integrator complex processes the 3' end of snRNA (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE1 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE1 [nucleoplasm] (Canis familiaris)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE1 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE1 [nucleoplasm] (Canis familiaris)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)
      - LEC [nucleoplasm] (Canis familiaris)
        
        ICE1 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        LEC [nucleoplasm] (Canis familiaris)
        
        ICE1 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S4C3

Gene Names

ICE1

Reference Genes

ENSEMBL:ENSCAFG00845024182.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845024182.1 ICE1

Other Identifiers

488059

Cfa.1989.1.A1_at

Cfa.6384.1.A1_s_at

CfaAffx.16210.1.S1_at

CfaAffx.16222.1.S1_s_at

GO:0000791

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0006886

GO:0008023

GO:0015030

GO:0016073

GO:0016604

GO:0030674

GO:0031334

GO:0035363

GO:0042795

GO:0042796

GO:0043226

GO:0045945

GO:0060090

GO:0065003

GO:0090316

Participates

as a component of

LEC [nucleoplasm] (Canis familiaris)

Inferred From

ICE1 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000164151

Ensembl

ENSCAFT00845042711, ENSCAFG00845024182, ENSCAFP00845033488