Reactome | INTS12 [nucleoplasm]

INTS12 [nucleoplasm]

Stable Identifier

R-CFA-6807456

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

INTS12, A0A8I3Q4C6

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - RNA polymerase II transcribes snRNA genes (Canis familiaris)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS12 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS12 [nucleoplasm] (Canis familiaris)
    - Integrator complex processes the 3' end of snRNA (Canis familiaris)
      - Integrator [nucleoplasm] (Canis familiaris)
        
        INTS12 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS12 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS12 [nucleoplasm] (Canis familiaris)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Canis familiaris)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS12 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS12 [nucleoplasm] (Canis familiaris)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Canis familiaris)
      - Integrator [nucleoplasm] (Canis familiaris)
        
        INTS12 [nucleoplasm] (Canis familiaris)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Canis familiaris)
        
        Integrator [nucleoplasm] (Canis familiaris)
        
        INTS12 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q4C6

Gene Names

INTS12

Reference Genes

BioGPS Gene:487889 INTS12

ENSEMBL:ENSCAFG00845028090.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845028090.1 INTS12

KEGG Gene (Canis lupus familiaris):487889 INTS12

Monarch:487889 INTS12

NCBI Gene:487889 INTS12

Reference Transcript

Other Identifiers

487889

CfaAffx.17023.1.S1_at

CfaAffx.17023.1.S1_s_at

GO:0005634

GO:0016073

GO:0016180

GO:0032039

GO:0043226

Participates

as a component of

Integrator [nucleoplasm] (Canis familiaris)

Inferred From

INTS12 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_013965486.1, XP_013965485.1, XP_013965484.1

OpenTargets

ENSG00000138785

Ensembl

ENSCAFT00845049595, ENSCAFP00845038903, ENSCAFG00845028090