Reactome | RPS3 [cytosol]

RPS3 [cytosol]

Stable Identifier

R-CFA-72369

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RPS3, E2RH47

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3 [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3 [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3 [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3 [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3 [cytosol] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3 [cytosol] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3 [cytosol] (Canis familiaris)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3 [cytosol] (Canis familiaris)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RH47

Gene Names

RPS3

Reference Genes

BioGPS Gene:476804 RPS3

ENSEMBL:ENSCAFG00040017211

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000005402.5 RPS3

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030018057.1 RPS3

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040017211.1 RPS3

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805028364 RPS3

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011844.1 RPS3

KEGG Gene (Canis lupus familiaris):476804 RPS3

Monarch:476804 RPS3

NCBI Gene:476804 RPS3

Reference Transcript

RefSeq:NM_001313777.1 RPS3

Other Identifiers

476804

Cfa.1477.1.S1_s_at

GO:0003723

GO:0003735

GO:0003824

GO:0003906

GO:0005198

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0015935

GO:0022627

GO:0031334

GO:0043226

GO:0045202

GO:0065003

GO:0140097

Participates

as a component of

40S ribosomal complex [cytosol] (Canis familiaris)

Other forms of this molecule

RPS3 [nucleoplasm]

Inferred From

RPS3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001300706.1

OpenTargets

ENSG00000149273

Ensembl

ENSCAFG00845011844, ENSCAFT00845021062, ENSCAFP00845016559

VGNC

45736

PDB

4V5Z, 6MTE, 6MTD

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