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RPS6 [cytosol]
Stable Identifier
R-CFA-72381
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
RPS6, A0A8I3NUU7
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Canis familiaris)
Nonsense-Mediated Decay (NMD) (Canis familiaris)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Canis familiaris)
Protein hydroxylation (Canis familiaris)
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Translation (Canis familiaris)
Eukaryotic Translation Initiation (Canis familiaris)
Cap-dependent Translation Initiation (Canis familiaris)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Canis familiaris)
Translation initiation complex formation (Canis familiaris)
Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Formation of a pool of free 40S subunits (Canis familiaris)
Release of 40S and 60S subunits from the 80S ribosome (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
eIF3 and eIF1A bind to the 40S subunit (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
40S:eIF3:eIF1A [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Formation of the ternary complex, and subsequently, the 43S complex (Canis familiaris)
Formation of the 43S pre-initiation complex (Canis familiaris)
40S:eIF3:eIF1A [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
GTP hydrolysis and joining of the 60S ribosomal subunit (Canis familiaris)
The 60S subunit joins the translation initiation complex (Canis familiaris)
40S:Met-tRNAi:mRNA [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
eIF2:GTP is hydrolyzed, eIFs are released (Canis familiaris)
40S:Met-tRNAi:mRNA [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
eIF5B:GTP is hydrolyzed and released (Canis familiaris)
80S:Met-tRNAi:mRNA [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Ribosomal scanning and start codon recognition (Canis familiaris)
Ribosomal scanning (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Start codon recognition (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
L13a-mediated translational silencing of Ceruloplasmin expression (Canis familiaris)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
SRP-dependent cotranslational protein targeting to membrane (Canis familiaris)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Canis familiaris)
SRP:polypeptide+signal:ribosome [cytosol] (Canis familiaris)
ribosome:mRNA:polypeptide+signal [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
ribosome:mRNA:polypeptide+signal [cytosol] (Canis familiaris)
80S ribosome [cytosol] (Canis familiaris)
40S ribosomal complex [cytosol] (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
MTOR signalling (Canis familiaris)
mTORC1-mediated signalling (Canis familiaris)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Canis familiaris)
RPS6 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NUU7
Gene Names
RPS6
Reference Genes
BioGPS Gene:474722 RPS6
ENSEMBL:ENSCAFG00845014546.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845014546.1 RPS6
KEGG Gene (Canis lupus familiaris):474722 RPS6
Monarch:474722 RPS6
NCBI Gene:474722 RPS6
Reference Transcript
RefSeq:NM_001252170.1 RPS6
Other Identifiers
474722
Cfa.10190.1.S1_s_at
GO:0003735
GO:0005198
GO:0005840
GO:0006412
GO:0043226
Participates
as an input of
KDM8:Fe2+ hydroxylates an arginine residue of RPS6 (Canis familiaris)
Phosphorylation of Ribosomal protein S6 by activated S6K1 (Canis familiaris)
as a component of
40S ribosomal complex [cytosol] (Canis familiaris)
Other forms of this molecule
RPS6 [nucleoplasm]
RPS6 [cytosol]
phospho-RPS6 [cytosol]
Inferred From
RPS6 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001239099.1
OpenTargets
ENSG00000137154
Ensembl
ENSCAFT00845026029
,
ENSCAFP00845020523
,
ENSCAFG00845014546
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