Reactome | RPL18A [cytosol]

RPL18A [cytosol]

Stable Identifier

R-CFA-72422

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RPL18A, A0A8I3PMS5

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)
- rRNA processing (Canis familiaris)
  - rRNA processing in the nucleus and cytosol (Canis familiaris)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Canis familiaris)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL18A [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PMS5

Gene Names

RPL18A

Reference Genes

BioGPS Gene:476672 RPL18A

ENSEMBL:ENSCAFG00845024769.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845024769.1 RPL18A

KEGG Gene (Canis lupus familiaris):476672 RPL18A

Monarch:476672 RPL18A

NCBI Gene:476672 RPL18A

Reference Transcript

RefSeq:XM_533877.5 RPL18A

Other Identifiers

476672

Cfa.10645.1.S1_at

Cfa.10645.1.S1_s_at

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0043226

Participates

as a component of

Inferred From

RPL18A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_533877.1

OpenTargets

ENSG00000105640

Ensembl

ENSCAFP00845034254, ENSCAFT00845043719, ENSCAFG00845024769

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