Reactome | RPL8 [cytosol]

RPL8 [cytosol]

Stable Identifier

R-CFA-72490

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RPL8, A0A8I3RWX4

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)
- rRNA processing (Canis familiaris)
  - rRNA processing in the nucleus and cytosol (Canis familiaris)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Canis familiaris)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        RPL8 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RWX4

Gene Names

RPL8

Reference Genes

BioGPS Gene:475130 RPL8

ENSEMBL:ENSCAFG00845012138.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845012138.1 RPL8

KEGG Gene (Canis lupus familiaris):475130 RPL8

Monarch:475130 RPL8

NCBI Gene:475130 RPL8

Reference Transcript

RefSeq:XM_853403.3 RPL8

Other Identifiers

475130

Cfa.4446.1.S1_s_at

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0014069

GO:0015934

GO:0022625

GO:0022626

GO:0042788

GO:0043226

GO:0098794

Participates

as a component of

Other forms of this molecule

RPL8 [nucleoplasm]

Inferred From

RPL8 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_858496.1

OpenTargets

ENSG00000161016

Ensembl

ENSCAFP00845016969, ENSCAFT00845021597, ENSCAFG00845012138

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