Reactome | MAPK3 [nucleoplasm]

MAPK3 [nucleoplasm]

Stable Identifier

R-CFA-73724

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

F1PXS7

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        ERK/MAPK targets (Canis familiaris)
        
        ERKs are inactivated (Canis familiaris)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Canis familiaris)
        
        MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Canis familiaris)
        
        MAPK3 dimer [nucleoplasm] (Canis familiaris)
        
        MAPK3 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1PXS7

Reference Genes

ENSEMBL:ENSCAFG00000018974

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000018974

Other Identifiers

CfaAffx.26169.1.S1_at

CfaAffx.28981.1.S1_s_at

GO:0000165

GO:0003674

GO:0004672

GO:0004707

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005886

GO:0005901

GO:0006464

GO:0006468

GO:0007165

GO:0007166

GO:0008150

GO:0010468

GO:0016301

GO:0035556

GO:0043167

GO:0043226

Participant Of

hasMember

MAPK monomers and dimers [nucleoplasm]

hasComponent

MAPK3 dimer [nucleoplasm]

Other forms of this molecule

phospho-p-T202-MAPK3 [cytosol]

MAPK3 [cytosol]

phospho-p-T202,Y204-MAPK3 [cytosol]

phospho-p-T202,Y204-MAPK3 [nucleoplasm]

Inferred From

MAPK3 [nucleoplasm] (Homo sapiens)

Cross References

Ensembl

ENSCAFG00000018974, ENSCAFT00000030132, ENSCAFP00000028002

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