Reactome | GRB2 [cytosol]

GRB2 [cytosol]

Stable Identifier

R-CFA-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

GRB2-1, A0A8I3PT69

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Costimulation by the CD28 family (Canis familiaris)
    - CD28 co-stimulation (Canis familiaris)
      - CD28 dependent Vav1 pathway (Canis familiaris)
        
        Activation of Cdc42 by pVav1 (Canis familiaris)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Activation of Rac1 by pVav1 (Canis familiaris)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Activation of Vav1 (Canis familiaris)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Grb2 binds CD28 (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Translocation of Vav1 to CD28 (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
    - Grb2 binds pBTLA (Canis familiaris)
      - GRB2 [cytosol] (Canis familiaris)
      - GRB2:pBTLA:HVEM [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
  - Signaling by the B Cell Receptor (BCR) (Canis familiaris)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Canis familiaris)
        
        BLNK:GRB2:SOS1:CIN85 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
- Cytokine Signaling in Immune system (Canis familiaris)
  - FLT3 Signaling (Canis familiaris)
    - Active FLT3:GRB2 binds SOS1 (Canis familiaris)
      - Active FLT3: GRB2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Active FLT3:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Active FLT3: GRB2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Canis familiaris)
        
        Active FLT3: GRB2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Canis familiaris)
        
        Active FLT3: GRB2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
    - SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Canis familiaris)
      - Active FLT3:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Active FLT3: GRB2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
  - Signaling by CSF3 (G-CSF) (Canis familiaris)
    - p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Canis familiaris)
      - CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-2 family signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Interleukin-15 signaling (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Canis familiaris)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-Y-GAB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Regulation of signaling by CBL (Canis familiaris)
        
        CBL ubiquitinates PI3K (Canis familiaris)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - DAP12 interactions (Canis familiaris)
    - DAP12 signaling (Canis familiaris)
      - Activation of RAC1 by VAV2/3 (Canis familiaris)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Phosphorylation of BTK by p-SYK (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-SYK/p-BTK [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of VAV and BTK to p-SLP-76 (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Release of p-PLCG1 (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - FCERI mediated Ca+2 mobilization (Canis familiaris)
      - Autophosphorylation of BTK/ITK (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Hydrolysis of PIP2 by PLCG (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Phosphorylation of TEC kinases by p-SYK (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
    - FCERI mediated MAPK activation (Canis familiaris)
      - Activation of RAC1 by VAV (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Autophosphorylation of PAK (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Interaction of GRB2:SOS complex with p-SHC1 (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Phosphorylation and activation of VAV (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Phosphorylation of SLP-76 by p-SYK (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of GRB2:SOS to p-5Y-LAT (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of PAK to the membrane by binding active RAC1 (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of VAV to p-SLP-76 (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - SOS mediated nucleotide exchange of RAS (SHC) (Canis familiaris)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
      - PI3K associates with phosphorylated GAB2 (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Recruitment of GRB2:SOS to p-10Y-NTAL (Canis familiaris)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        p-SHC1:GRB2:SOS [cytosol] (Canis familiaris)
        
        GRB2-1:SOS1 [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Detachment of WASP/WAVE (Canis familiaris)
        
        Mother filament:branching complex [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - Src phosphorylate WASP,N-WASP (Canis familiaris)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
      - WIP binds WASP,N-WASP, activating them (Canis familiaris)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)
        
        SH3 domain proteins [cytosol] (Canis familiaris)
        
        GRB2 [cytosol] (Canis familiaris)