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phospho-IRS1 [cytosol]
Stable Identifier
R-CFA-74772
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-Y-IRS1, A0A8I3NVW9
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
Active ALK phosphorylates IRS1 (Canis familiaris)
Active ALK:pY-IRS1 [plasma membrane] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS activation (Canis familiaris)
Dissociation of IRS-P from insulin receptor (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
Phosphorylation of IRS (Canis familiaris)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
SOS-mediated signalling (Canis familiaris)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
Signal attenuation (Canis familiaris)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Canis familiaris)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
SOS-mediated signalling (Canis familiaris)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Canis familiaris)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
phospho-IRS1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NVW9
Gene Names
IRS1
Reference Genes
ENSEMBL:ENSCAFG00845015145.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845015145.1 IRS1
Other Identifiers
486148
CfaAffx.16260.1.S1_at
CfaAffx.16264.1.S1_s_at
GO:0001784
GO:0005158
GO:0005159
GO:0005634
GO:0005654
GO:0005829
GO:0005886
GO:0005901
GO:0005975
GO:0006091
GO:0006629
GO:0007165
GO:0008286
GO:0010907
GO:0019221
GO:0023052
GO:0030159
GO:0032000
GO:0032868
GO:0032869
GO:0043226
GO:0043491
GO:0043548
GO:0045725
GO:0046326
GO:0046628
GO:0046676
GO:0048009
GO:0055085
GO:0060090
Participates
as a component of
Active ALK:pY-IRS1 [plasma membrane] (Canis familiaris)
as a member of
p-Y-IRS1,p-Y-IRS2 [cytosol] (Canis familiaris)
Other forms of this molecule
phospho-IRS1 [plasma membrane]
IRS1 [plasma membrane]
IRS1 [cytosol]
phospho-IRS1 [plasma membrane]
Inferred From
p-Y-IRS1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000169047
Ensembl
ENSCAFG00845015145
,
ENSCAFP00845021279
,
ENSCAFT00845027041
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