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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
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Analysis Gene Expression
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Cytomics
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Citing us
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Analyse gene expression
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PIK3R1 [cytosol]
Stable Identifier
R-CFA-74789
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
PIK3R1, A0A8I3N971
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
RET signaling (Canis familiaris)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
Tie2 Signaling (Canis familiaris)
Interaction of Tie2 and p85 of PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p85 bound to Tie2 [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
GPVI-mediated activation cascade (Canis familiaris)
GPVI stimulates PI3K beta, gamma (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Canis familiaris)
PI3K alpha, beta, gamma [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Costimulation by the CD28 family (Canis familiaris)
CD28 co-stimulation (Canis familiaris)
CD28 dependent PI3K/Akt signaling (Canis familiaris)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K binds CD28 (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K binds ICOS (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
p-CD19:VAV binds PI3K and GRB2 (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K bound to TRAT [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Recruitment of PI3K to plasma membrane (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K bound to TRAT [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Canis familiaris)
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:p-Y-GRB10 binds PIK3R1 (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Regulation of signaling by CBL (Canis familiaris)
CBL ubiquitinates PI3K (Canis familiaris)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Canis familiaris)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p85-containing Class 1A PI3Ks [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K beta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K delta [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Interleukin-7 signaling (Canis familiaris)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Canis familiaris)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Canis familiaris)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Canis familiaris)
PI3K regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits [plasma membrane] (Canis familiaris)
PI3K regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
DAP12 interactions (Canis familiaris)
DAP12 signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p85 regulatory unit of PI3K binds p-6Y-SYK (Canis familiaris)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
Role of LAT2/NTAL/LAB on calcium mobilization (Canis familiaris)
PI3K associates with phosphorylated GAB2 (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Phosphorylation of PIP2 to PIP3 by PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Role of phospholipids in phagocytosis (Canis familiaris)
PI3K binds to p-6Y-SYK (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Phospholipid metabolism (Canis familiaris)
PI Metabolism (Canis familiaris)
Synthesis of PIPs at the plasma membrane (Canis familiaris)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Canis familiaris)
PIK3C(1) [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Canis familiaris)
PIK3(2) [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K bound to TRAT [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
CD28:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
ICOS:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K bound to TRAT [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC1,RAC2,RHOG activate PI3K (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS:GTP binds PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p21 RAS:GTP:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by Erythropoietin (Canis familiaris)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K bound to EPOR [plasma membrane] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Canis familiaris)
PI3K alpha, gamma [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (q) signalling events (Canis familiaris)
G alpha (q) inhibits PI3K alpha (Canis familiaris)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
PI3K binds membrane-associated estrogen receptors (Canis familiaris)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PTK2 is recruited to methylated ESR1 (Canis familiaris)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
Active ALK recruits PI3K (Canis familiaris)
Active ALK:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K synthesizes PIP3 downstream of ALK (Canis familiaris)
Active ALK:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by EGFR (Canis familiaris)
GAB1 signalosome (Canis familiaris)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by ERBB4 (Canis familiaris)
PI3K events in ERBB4 signaling (Canis familiaris)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by FGFR (Canis familiaris)
Signaling by FGFR1 (Canis familiaris)
Downstream signaling of activated FGFR1 (Canis familiaris)
PI-3K cascade:FGFR1 (Canis familiaris)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by FGFR2 (Canis familiaris)
Downstream signaling of activated FGFR2 (Canis familiaris)
PI-3K cascade:FGFR2 (Canis familiaris)
Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR2:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by FGFR3 (Canis familiaris)
Downstream signaling of activated FGFR3 (Canis familiaris)
PI-3K cascade:FGFR3 (Canis familiaris)
Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR3:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by FGFR4 (Canis familiaris)
Downstream signaling of activated FGFR4 (Canis familiaris)
PI-3K cascade:FGFR4 (Canis familiaris)
Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
Activated FGFR4:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Activated FGFR bound to PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by MET (Canis familiaris)
MET activates PI3K/AKT signaling (Canis familiaris)
MET bound PI3K generates PIP3 (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by NTRKs (Canis familiaris)
Signaling by NTRK1 (TRKA) (Canis familiaris)
PI3K/AKT activation (Canis familiaris)
Active IRS recruits PI3K to the plasma membrane and activates it (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Downstream signal transduction (Canis familiaris)
PI3-kinase binds to the active receptor (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Canis familiaris)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by SCF-KIT (Canis familiaris)
Direct recruitment of PI3K to p-KIT (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Synthesis of PIP3 from PIP2 by PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Canis familiaris)
IGF1R signaling cascade (Canis familiaris)
IRS-related events triggered by IGF1R (Canis familiaris)
IRS-mediated signalling (Canis familiaris)
PI3K Cascade (Canis familiaris)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Canis familiaris)
PI3K-containing complexes [cytosol] (Canis familiaris)
Activated FGFR bound to PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Canis familiaris)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
p-AXL binds PI3K (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Canis familiaris)
PI3K [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
CDC42 GTPase cycle (Canis familiaris)
CDC42 GAPs stimulate CDC42 GTPase activity (Canis familiaris)
CDC42 GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 GAPs stimulate RAC1 GTPase activity (Canis familiaris)
RAC1 GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC1 binds effectors at the plasma membrane (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC1:GTP:RAC1 effectors [plasma membrane] (Canis familiaris)
RAC1 effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC2 GTPase cycle (Canis familiaris)
RAC2 GAPs stimulate RAC2 GTPase activity (Canis familiaris)
RAC2 GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC2 binds effectors at the plasma membrane (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Canis familiaris)
RAC2 plasma membrane effectors [cytosol] (Canis familiaris)
PI3K alpha [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RAC3 GTPase cycle (Canis familiaris)
RAC3 GAPs stimulate RAC3 GTPase activity (Canis familiaris)
RAC3 GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOA GTPase cycle (Canis familiaris)
RHOA GAPs stimulate RHOA GTPase activity (Canis familiaris)
RHOA GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOB GTPase cycle (Canis familiaris)
RHOB GAPs stimulate RHOB GTPase activity (Canis familiaris)
RHOB GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOC GTPase cycle (Canis familiaris)
RHOC GAPs stimulate RHOC GTPase activity (Canis familiaris)
RHOC GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOD GTPase cycle (Canis familiaris)
RHOD GAPs stimulate RHOD GTPase activity (Canis familiaris)
RHOD GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOF GTPase cycle (Canis familiaris)
RHOF GAPs stimulate RHOF GTPase activity (Canis familiaris)
RHOF GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOG GTPase cycle (Canis familiaris)
RHOG GAPs stimulate RHOG GTPase activity (Canis familiaris)
RHOG GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOJ GTPase cycle (Canis familiaris)
RHOJ GAPs stimulate RHOJ GTPase activity (Canis familiaris)
RHOJ GAPs [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOU GTPase cycle (Canis familiaris)
RHOU binds effectors at the plasma membrane (Canis familiaris)
RHOU effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOU:GTP:RHOU effectors [plasma membrane] (Canis familiaris)
RHOU effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOV GTPase cycle (Canis familiaris)
RHOV binds effectors at the plasma membrane (Canis familiaris)
RHOV effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RHOV:GTP:RHOV effectors [plasma membrane] (Canis familiaris)
RHOV effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RND1 GTPase cycle (Canis familiaris)
RND1 binds effectors (Canis familiaris)
RND1 effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RND1:GTP:RND1 effectors [plasma membrane] (Canis familiaris)
RND1 effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RND2 GTPase cycle (Canis familiaris)
RND2 binds effectors (Canis familiaris)
RND2 effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RND2:GTP:RND2 effectors [plasma membrane] (Canis familiaris)
RND2 effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RND3 GTPase cycle (Canis familiaris)
RND3 binds effectors (Canis familiaris)
RND3 effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
RND3:GTP:RND3 effectors [plasma membrane] (Canis familiaris)
RND3 effectors [cytosol] (Canis familiaris)
PIK3R1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N971
Gene Names
PIK3R1
Reference Genes
BioGPS Gene:487235 PIK3R1
ENSEMBL:ENSCAFG00845011717.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011717.1 PIK3R1
Monarch:487235 PIK3R1
NCBI Gene:487235 PIK3R1
Reference Transcript
RefSeq:XM_014108824.1 PIK3R1
RefSeq:XM_014108822.1 PIK3R1
RefSeq:XM_845248.4 PIK3R1
Other Identifiers
487235
Cfa.4502.1.S1_at
Cfa.8982.1.A1_at
CfaAffx.12301.1.S1_s_at
GO:0001678
GO:0001784
GO:0001953
GO:0002376
GO:0002687
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005634
GO:0005737
GO:0005783
GO:0005794
GO:0005801
GO:0005829
GO:0005911
GO:0005943
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006886
GO:0006913
GO:0007010
GO:0007155
GO:0007162
GO:0007165
GO:0008286
GO:0008625
GO:0008630
GO:0010592
GO:0012501
GO:0015031
GO:0016020
GO:0019209
GO:0019221
GO:0019903
GO:0023052
GO:0030154
GO:0030183
GO:0030316
GO:0032760
GO:0032869
GO:0033120
GO:0034143
GO:0034330
GO:0034644
GO:0034976
GO:0035655
GO:0036312
GO:0042307
GO:0043066
GO:0043125
GO:0043226
GO:0043491
GO:0043559
GO:0043560
GO:0045671
GO:0045944
GO:0046935
GO:0046982
GO:0048009
GO:0048471
GO:0048661
GO:0048856
GO:0048870
GO:0050821
GO:0051491
GO:0051492
GO:0051497
GO:0060396
GO:0072659
GO:0097529
GO:0098542
GO:0098772
GO:0120183
GO:1900103
GO:1903076
GO:1990578
Participates
as a candidate of
RND2 effectors [cytosol] (Canis familiaris)
RHOA GAPs [cytosol] (Canis familiaris)
RND3 effectors [cytosol] (Canis familiaris)
RHOC GAPs [cytosol] (Canis familiaris)
RHOV effectors [cytosol] (Canis familiaris)
CDC42 GAPs [cytosol] (Canis familiaris)
RAC2 GAPs [cytosol] (Canis familiaris)
RHOD GAPs [cytosol] (Canis familiaris)
RAC1 GAPs [cytosol] (Canis familiaris)
RHOF GAPs [cytosol] (Canis familiaris)
RHOB GAPs [cytosol] (Canis familiaris)
RHOG GAPs [cytosol] (Canis familiaris)
RHOJ GAPs [cytosol] (Canis familiaris)
RAC3 GAPs [cytosol] (Canis familiaris)
RND1 effectors [cytosol] (Canis familiaris)
PI3K regulatory subunits [cytosol] (Canis familiaris)
as a member of
RHOU effectors [cytosol] (Canis familiaris)
PI3K-regulatory subunits [cytosol] (Canis familiaris)
PI3K-regulatory subunit [cytosol] (Canis familiaris)
as a component of
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Canis familiaris)
active FLT3:p-Y GRB10:PIK3R1 [plasma membrane] (Canis familiaris)
PIK3CD:PIK3R1 [cytosol] (Canis familiaris)
PIK3CB:PIK3R1 [cytosol] (Canis familiaris)
Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Canis familiaris)
GRB2:GAB1:PIK3R1 [cytosol] (Canis familiaris)
PIK3CA:PIK3R1 [cytosol] (Canis familiaris)
as an input of
Active FLT3:p-Y-GRB10 binds PIK3R1 (Canis familiaris)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)
Other forms of this molecule
PIK3R1 [cytosol]
PIK3R1 [plasma membrane]
Inferred From
PIK3R1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_013964299.1
,
XP_013964297.1
,
XP_850341.1
OpenTargets
ENSG00000145675
Ensembl
ENSCAFT00845020842
,
ENSCAFG00845011717
,
ENSCAFP00845016363
© 2024
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