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CASP8 [cytosol]
Stable Identifier
R-CFA-75975
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
CASP8(217-374), Q38JA9
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
CLEC7A/inflammasome pathway (Canis familiaris)
ASC binds Caspase-8 complex (Canis familiaris)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Canis familiaris)
MALT1:active caspase-8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
MALT1:active caspase-8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Caspase-8 binds MALT (Canis familiaris)
MALT1:active caspase-8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Caspase-8 cleaves IL1B precursor (Canis familiaris)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Canis familiaris)
MALT1:active caspase-8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
TRIF-mediated programmed cell death (Canis familiaris)
Caspase-8 processing within TLR4 complex (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
CASP8 cleaves N4BP1 at D424, D490 (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
N4BP1 binds IKBKG (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Apoptosis (Canis familiaris)
Apoptotic execution phase (Canis familiaris)
Apoptotic cleavage of cellular proteins (Canis familiaris)
Caspase-mediated cleavage of cytoskeletal proteins (Canis familiaris)
Caspase mediated cleavage of vimentin at IDVD (259) (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Caspase-mediated cleavage of plectin-1 (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Translocation of active caspase-8 to the mitochondrial membrane (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Caspase activation via extrinsic apoptotic signalling pathway (Canis familiaris)
Caspase activation via Death Receptors in the presence of ligand (Canis familiaris)
Caspase-8 processing within TLR4 complex (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Regulation by c-FLIP (Canis familiaris)
Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Intrinsic Pathway for Apoptosis (Canis familiaris)
Activation, myristolyation of BID and translocation to mitochondria (Canis familiaris)
Caspase-8 activates BID by cleavage (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
Regulation of necroptotic cell death (Canis familiaris)
RIPK1 is cleaved by CASP8 (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
RIPK3 is cleaved by CASP8 (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
RIPK1 is cleaved by CASP8 (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
active caspase-8 [cytosol] (Canis familiaris)
Caspase-8 dimer [cytosol] (Canis familiaris)
CASP8 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:Q38JA9
Gene Names
CASP8
Reference Genes
BioGPS Gene:488473 CASP8
ENSEMBL:ENSCAFG00845030024.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845030024.1 CASP8
KEGG Gene (Canis lupus familiaris):488473 CASP8
Monarch:488473 CASP8
NCBI Gene:488473 CASP8
Reference Transcript
RefSeq:XM_005640425.1 CASP8
RefSeq:XM_005640424.2 CASP8
RefSeq:XM_005640427.1 CASP8
RefSeq:XM_005640423.1 CASP8
RefSeq:NM_001048029.1 CASP8
RefSeq:XM_005640426.2 CASP8
Other Identifiers
488473
Cfa.1722.1.S1_at
CfaAffx.18878.1.S1_s_at
GO:0002376
GO:0003824
GO:0004197
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0008233
GO:0008234
GO:0012501
GO:0016787
GO:0023052
GO:0030154
GO:0030163
GO:0031264
GO:0031265
GO:0031625
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042802
GO:0042981
GO:0043123
GO:0043124
GO:0043226
GO:0045651
GO:0045862
GO:0048856
GO:0051603
GO:0051604
GO:0060546
GO:0071260
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097342
GO:0140096
Participates
as a component of
Caspase-8 dimer [cytosol] (Canis familiaris)
Other forms of this molecule
CASP8 [cytosol]
CASP8 [mitochondrial outer membrane]
CASP8 [mitochondrial outer membrane]
CASP8 [cytosol]
CASP8 [cytosol]
Inferred From
CASP8(217-374) [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005640481.1
,
NP_001041494.1
,
XP_005640483.1
,
XP_005640484.1
,
XP_005640482.1
,
XP_005640480.1
OpenTargets
ENSG00000064012
Ensembl
ENSCAFP00845041772
,
ENSCAFT00845053200
,
ENSCAFG00845030024
VGNC
38736
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