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HMGB1 [extracellular region]
Stable Identifier
R-CFA-879382
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
Q6YKA4
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Innate Immune System (Canis familiaris)
Advanced glycosylation endproduct receptor signaling (Canis familiaris)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Canis familiaris)
TRAF6 mediated NF-kB activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Neutrophil degranulation (Canis familiaris)
Exocytosis of ficolin-rich granule lumen proteins (Canis familiaris)
Ficolin-rich granule lumen proteins [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Exocytosis of secretory granule lumen proteins (Canis familiaris)
Secretory granule lumen proteins [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:Q6YKA4
Reference Genes
BioGPS Gene:403170
ENSEMBL:ENSCAFG00845021967
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000006597.6
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030022196.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040016920.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805028954
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845021967.1
KEGG Gene (Canis lupus familiaris):403170
Monarch:403170
NCBI Gene:403170
Reference Transcript
RefSeq:NM_001002937.2
RefSeq:XM_014107323.1
Other Identifiers
403170
Cfa.416.1.S1_at
Cfa.416.1.S1_s_at
CfaAffx.10841.1.S1_s_at
GO:0003677
GO:0005634
GO:0043226
Participates
as a member of
Secretory granule lumen proteins [extracellular region] (Canis familiaris)
Ficolin-rich granule lumen proteins [extracellular region] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
Other forms of this molecule
HMGB1 [secretory granule lumen]
HMGB1 [ficolin-1-rich granule lumen]
HMGB1 [nucleoplasm]
HC23,45-HMGB1 [extracellular region]
Inferred From
HMGB1 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001002937.1
,
XP_013962798.1
Ensembl
ENSCAFG00845021967
,
ENSCAFP00845030356
,
ENSCAFT00845038767
VGNC
59082
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