Reactome | FBXL4 [cytosol]

FBXL4 [cytosol]

Stable Identifier

R-CFA-8850899

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

FBXL4, A0A8I3MXZ3

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXL4 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MXZ3

Gene Names

FBXL4

Reference Genes

ENSEMBL:ENSCAFG00845005491.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845005491.1 FBXL4

Reference Transcript

RefSeq:XM_863036.3 FBXL4

Other Identifiers

481932

CfaAffx.6144.1.S1_at

GO:0000422

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005758

GO:0006914

GO:0007005

GO:0016607

GO:0043226

Participates

as a member of

Inferred From

FBXL4 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_868129.2

OpenTargets

ENSG00000112234

Ensembl

ENSCAFP00845007647, ENSCAFT00845009783, ENSCAFG00845005491

Cite Us!