Reactome | FBXO40 [cytosol]

FBXO40 [cytosol]

Stable Identifier

R-CFA-8862612

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

FBXO40, A0A8I3PHV0

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Class I MHC mediated antigen processing & presentation (Canis familiaris)
    - Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
      - Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - Polyubiquitination of substrate (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
        
        E3:Ub:substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - Release of E3 from polyubiquitinated substrate (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
        
        E3:Ub:substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXO40 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PHV0

Gene Names

FBXO40

Reference Genes

BioGPS Gene:488004 FBXO40

ENSEMBL:ENSCAFG00845020486.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845020486.1 FBXO40

KEGG Gene (Canis lupus familiaris):488004 FBXO40

Monarch:488004 FBXO40

NCBI Gene:488004 FBXO40

Reference Transcript

RefSeq:XM_005639548.2 FBXO40

Other Identifiers

488004

Cfa.1572.1.A1_at

CfaAffx.17891.1.S1_at

GO:0003824

GO:0005515

GO:0005737

GO:0008270

GO:0016740

GO:0030154

GO:0042692

GO:0048856

GO:0061630

GO:0140096

Participates

as a member of

F-box protein [cytosol] (Canis familiaris)

Inferred From

FBXO40 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005639605.1

OpenTargets

ENSG00000163833

Ensembl

ENSCAFT00845036090, ENSCAFG00845020486, ENSCAFP00845028244

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