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misfolded CFTR [endoplasmic reticulum membrane]
Stable Identifier
R-CFA-8868730-2
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
endoplasmic reticulum membrane
Synonyms
Q5U820
Locations in the PathwayBrowser
Expand all
Autophagy (Canis familiaris)
Macroautophagy (Canis familiaris)
Selective autophagy (Canis familiaris)
Aggrephagy (Canis familiaris)
Aggresome dissociates from dynein and microtubule (Canis familiaris)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
Parkin transfers Ub to misfolded proteins (Canis familiaris)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
Ub-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Canis familiaris)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Canis familiaris)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
PolyUb-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Canis familiaris)
Ub-Misfolded Proteins [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
CFTR transits to the plasma membrane (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)
Ub-misfolded nascent CFTR [cytosol] (Canis familiaris)
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:Q5U820
Reference Genes
BioGPS Gene:492302
ENSEMBL:ENSCAFG00030012224
KEGG:cfa:492302
Monarch:492302
NCBI Gene:492302
UCSC:Q5U820
Reference Transcript
RefSeq:NM_001007143.1
Participates
as a member of
Homologues of misfolded CFTR [endoplasmic reticulum membrane] (Canis familiaris)
Other forms of this molecule
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
PolyUb-CFTR [plasma membrane]
CFTR [lysosomal membrane]
CFTR [Golgi-associated vesicle membrane]
CFTR [endosome membrane]
PolyUb-CFTR [endosome membrane]
CFTR [plasma membrane]
Inferred From
CFTR [endoplasmic reticulum membrane]
(Homo sapiens)
misfolded CFTR [endoplasmic reticulum membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001007144.1
VGNC
39180
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