Reactome | SYT1 [clathrin-coated endocytic vesicle membrane]

SYT1 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CFA-8869113

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

F1PNW4

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dissociation of clathrin-associated proteins (Canis familiaris)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:F1PNW4

Reference Genes

ENSEMBL:ENSCAFG00000005766

Reference Transcript

RefSeq:XM_539696.4

Other Identifiers

482579

AAEX03009878

Cfa.1368.1.A1_at

CfaAffx.9607.1.S1_at

CfaAffx.9611.1.S1_at

ENSCAFG00000005766

ENSCAFP00000008632

ENSCAFT00000009301

EntrezGene:482579

EntrezGene:SYT1

GO:0000149

GO:0000902

GO:0001786

GO:0003674

GO:0005509

GO:0005544

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005794

GO:0005886

GO:0006810

GO:0007267

GO:0007269

GO:0008021

GO:0008150

GO:0008289

GO:0014059

GO:0016020

GO:0016021

GO:0016079

GO:0016192

GO:0017075

GO:0017156

GO:0017158

GO:0019905

GO:0030141

GO:0030154

GO:0030276

GO:0030424

GO:0030672

GO:0031045

GO:0031410

GO:0040007

GO:0042734

GO:0043005

GO:0043167

GO:0043226

GO:0048306

GO:0048488

GO:0048791

GO:0048856

GO:0050750

GO:0050806

GO:0051966

GO:0061024

GO:0061669

GO:0061891

GO:0070382

GO:0071277

GO:0071911

GO:0098746

GO:0098978

GO:0099502

GO:1903235

GO:1903861

IPR000008

IPR001565

IPR015428

IPR035892

PF00168

PR00360

PR00399

SM00239

SYT1

SYT1-201

UPI00005A2DFD

VGNC:47040

XM_539696

XP_022283833

XP_539696

Participant Of

hasComponent

SYT1 dimer [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]

SYT1 [clathrin-sculpted glutamate transport vesicle membrane]

SYT1 [plasma membrane]

SYT1 [clathrin-sculpted monoamine transport vesicle membrane]

Inferred From

SYT1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_539696.2