Reactome | LRIG1 [plasma membrane]

LRIG1 [plasma membrane]

Stable Identifier

R-CFA-8875434

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

Ub-LRIG1, A0A8I3N8H2

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by MET (Canis familiaris)
    - Negative regulation of MET activity (Canis familiaris)
      - EPS15 and HGS bind ubiquitinated MET (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Canis familiaris)
        
        MET:Ub-LRIG1 [plasma membrane] (Canis familiaris)
        
        LRIG1 [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Canis familiaris)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin,(MET:Ub-LRIG1) [plasma membrane] (Canis familiaris)
        
        MET:Ub-LRIG1 [plasma membrane] (Canis familiaris)
        
        LRIG1 [plasma membrane] (Canis familiaris)
      - USP8 deubiquitinates LRIG1 (Canis familiaris)
        
        MET:Ub-LRIG1 [plasma membrane] (Canis familiaris)
        
        LRIG1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N8H2

Gene Names

LRIG1

Reference Genes

ENSEMBL:ENSCAFG00845011565.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011565.1 LRIG1

Other Identifiers

484698

CfaAffx.10951.1.S1_at

GO:0005515

GO:0007605

GO:0016020

GO:0022405

GO:0032474

GO:0048856

GO:0050877

GO:0060384

Participates

as a component of

MET:Ub-LRIG1 [plasma membrane] (Canis familiaris)

Other forms of this molecule

LRIG1 [plasma membrane]

Inferred From

Ub-LRIG1 [plasma membrane] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (Ub [cytosol]) at unknown position

Modification

Ub [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

OpenTargets

ENSG00000144749

Ensembl

ENSCAFP00845016074, ENSCAFT00845020503, ENSCAFG00845011565

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