IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2

Stable Identifier
R-CFA-8986994
Type
Reaction [BlackBoxEvent]
Species
Canis familiaris
Compartment
Synonyms
JAK1 and TYK2 are phosphorylated by IL26:IL20RA:JAK1:IL10RB:TYK2 receptor complex, JAK1 and TYK2 are phosphorylated after il26 il26 receptor interaction
Locations in the PathwayBrowser
Summation

This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL26:IL20RA:JAK1:IL10RB:TYK2 [plasma membrane]
Physical Entity
Activity
Inferred From