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IL22:p?Y251,p?Y301?IL22RA1:p?JAK1:IL10RB:p?TYK2:STAT3 phosphorylates STAT3

Stable Identifier
Reaction [BlackBoxEvent]
Canis familiaris
STAT3 is phosphorylated by IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 activated receptor complex., STAT3 is phosphorylated by the IL22 activated receptor complex.
Locations in the PathwayBrowser

This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping in Ensembl Compara. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on the Ensembl Compara system see also: Gene orthology/paralogy prediction method.

Participant Of
Catalyst Activity
Catalyst Activity
transmembrane receptor protein tyrosine kinase activity of IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane]
Physical Entity
Inferred From