Reactome | NTF4 homodimer [extracellular region]

NTF4 homodimer [extracellular region]

Stable Identifier

R-CFA-9025082

Type

Complex

Species

Canis familiaris

Compartment

extracellular region

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        Activator:PI3K [plasma membrane] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4 homodimer [extracellular region] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - Activator:PI3K [plasma membrane] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4 homodimer [extracellular region] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by NTRKs (Canis familiaris)
    - Signaling by NTRK2 (TRKB) (Canis familiaris)
      - Activated NTRK2 signals through FRS2 and FRS3 (Canis familiaris)
        
        Activated NTRK2 binds FRS2 (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4 homodimer [extracellular region] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4 homodimer [extracellular region] (Canis familiaris)
        
        NTRK2-phosphorylated FRS2 binds GRB2 (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4 homodimer [extracellular region] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2 [plasma membrane] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4 homodimer [extracellular region] (Canis familiaris)
      - Activated NTRK2 signals through PLCG1 (Canis familiaris)
        
        Activated PCLG1 dissociates from NTRK2 (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4 homodimer [extracellular region] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2:p-4Y-PLCG1 [plasma membrane] (Canis familiaris)
        
        BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 homodimer [plasma membrane] (Canis familiaris)
        
        NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)
        
        NTF4 homodimer [extracellular region] (Canis familiaris)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

x 2 NTF4 [extracellular region] (Canis familiaris)

Participates

as a component of

NTF4:p-5Y-NTRK2 [plasma membrane] (Canis familiaris)

Inferred From

NTF4 homodimer [extracellular region] (Homo sapiens)