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USP18 [cytosol]
Stable Identifier
R-CFA-912325
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
USP18, A0A8I3Q883
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Interferon Signaling (Canis familiaris)
Antiviral mechanism by IFN-stimulated genes (Canis familiaris)
ISG15 antiviral mechanism (Canis familiaris)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Interferon alpha/beta signaling (Canis familiaris)
Regulation of IFNA/IFNB signaling (Canis familiaris)
UBP43 binds IFNAR2 and prevents JAK1 interaction (Canis familiaris)
IFNAR2c:UBP43 [plasma membrane] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Regulation of NF-kappa B signaling (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
USP18 deubiquitinates TAK1:TAB1 (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18:MAP3K7:TAB1 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
USP18:PolyUb-MAP3K7:TAB1 [cytosol] (Canis familiaris)
USP18 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3Q883
Gene Names
USP18
Reference Genes
ENSEMBL:ENSCAFG00845030962.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845030962.1 USP18
Other Identifiers
486763
CfaAffx.24933.1.S1_at
GO:0003824
GO:0004843
GO:0006508
GO:0008233
GO:0008234
GO:0016579
GO:0016787
GO:0036211
GO:0140096
Participates
as a component of
USP18:MAP3K7:TAB1 [cytosol] (Canis familiaris)
USP18:PolyUb-MAP3K7:TAB1 [cytosol] (Canis familiaris)
IFNAR2c:UBP43 [plasma membrane] (Canis familiaris)
CHUK:IKBKB:IKBKG:USP18 [cytosol] (Canis familiaris)
as an input of
UBP43 binds IFNAR2 and prevents JAK1 interaction (Canis familiaris)
USP18 binds IKBKG within IKK complex (Canis familiaris)
Inferred From
USP18 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000184979
Ensembl
ENSCAFT00845055026
,
ENSCAFG00845030962
,
ENSCAFP00845043265
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