Reactome | ATP6V1B2 [cytosol]

ATP6V1B2 [cytosol]

Stable Identifier

R-CFA-912598

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

ATP6V1B2, A0A8I3Q2N9

Locations in the PathwayBrowser

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Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular response to starvation (Canis familiaris)
    - Amino acids regulate mTORC1 (Canis familiaris)
      - RRAGA,B exchanges GDP for GTP (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
      - RRAGA,B hydrolyzes GTP (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
      - RRAGC,D exchanges GTP for GDP (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
      - RRAGC,D hydrolyzes GTP (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
      - mTORC1 binds RHEB:GTP (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Canis familiaris)
        
        v-ATPase:Ragulator [lysosomal membrane] (Canis familiaris)
        
        v-ATPase [lysosomal membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - ROS and RNS production in phagocytes (Canis familiaris)
    - Intraphagosomal pH is lowered to 5 by V-ATPase (Canis familiaris)
      - V-ATPase [phagocytic vesicle membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by Insulin receptor (Canis familiaris)
    - Insulin receptor recycling (Canis familiaris)
      - ATP6AP1 binds V-ATPase (Canis familiaris)
        
        V-ATPase [endosome membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Canis familiaris)
        
        V-ATPase [endosome membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
      - Endosome acidification (Canis familiaris)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Canis familiaris)
        
        V-ATPase [endosome membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)

Transport of small molecules (Canis familiaris)

- Ion channel transport (Canis familiaris)
  - ATP6AP1 binds V-ATPase (Canis familiaris)
    - V-ATPase [endosome membrane] (Canis familiaris)
      - ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
    - V-ATPase:ATP6AP1 [endosome membrane] (Canis familiaris)
      - V-ATPase [endosome membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
- Iron uptake and transport (Canis familiaris)
  - Transferrin endocytosis and recycling (Canis familiaris)
    - ATP6AP1 binds V-ATPase (Canis familiaris)
      - V-ATPase [endosome membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
      - V-ATPase:ATP6AP1 [endosome membrane] (Canis familiaris)
        
        V-ATPase [endosome membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)
    - Acidification of Tf:TfR1 containing endosome (Canis familiaris)
      - V-ATPase:ATP6AP1 [endosome membrane] (Canis familiaris)
        
        V-ATPase [endosome membrane] (Canis familiaris)
        
        ATP6V1 [cytosol] (Canis familiaris)
        
        ATP6V1B trimer [cytosol] (Canis familiaris)
        
        ATP6V1B [cytosol] (Canis familiaris)
        
        ATP6V1B2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q2N9

Gene Names

ATP6V1B2

Reference Genes

ENSEMBL:ENSCAFG00845029095.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029095.1 ATP6V1B2

Other Identifiers

486137

Cfa.20851.1.S1_s_at

Cfa.2297.1.A1_at

CfaAffx.15827.1.S1_s_at

GO:0000221

GO:0001726

GO:0005215

GO:0005524

GO:0005737

GO:0005773

GO:0005829

GO:0005886

GO:0005902

GO:0006811

GO:0016192

GO:0016324

GO:0033180

GO:0043226

GO:0043231

GO:0046034

GO:0046961

GO:0055085

GO:0055086

GO:0097401

GO:0098793

GO:0140657

GO:1901135

GO:1902600

Participates

as a member of

ATP6V1B [cytosol] (Canis familiaris)

Inferred From

ATP6V1B2 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000147416

Ensembl

ENSCAFT00845051491, ENSCAFP00845040403, ENSCAFG00845029095

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