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phospho-BRCA1 [nucleoplasm]
Stable Identifier
R-CFA-9707290
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
nucleoplasm
Synonyms
K6PolyUb,p-S1387,S1423,S1457,S1524-BRCA1, A0A8I3N406
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
G2/M DNA damage checkpoint (Canis familiaris)
CHEK2 is recruited to DNA DSBs (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
DNA Repair (Canis familiaris)
DNA Double-Strand Break Repair (Canis familiaris)
DNA Double Strand Break Response (Canis familiaris)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
CHEK2 is recruited to DNA DSBs (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
CHEK2 phosphorylates BRCA1 (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
phospho-BRCA1 [nucleoplasm] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N406
Gene Names
BRCA1
Reference Genes
ENSEMBL:ENSCAFG00845006070.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006070.1 BRCA1
Other Identifiers
403437
Cfa.140.1.S1_s_at
GO:0000152
GO:0000209
GO:0000228
GO:0000278
GO:0000724
GO:0000793
GO:0000794
GO:0000800
GO:0000976
GO:0001216
GO:0001673
GO:0001741
GO:0002039
GO:0003677
GO:0003684
GO:0003713
GO:0003723
GO:0003824
GO:0004842
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005886
GO:0006281
GO:0006301
GO:0006302
GO:0006310
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006629
GO:0006631
GO:0006633
GO:0006974
GO:0007010
GO:0007049
GO:0007059
GO:0007095
GO:0007098
GO:0008270
GO:0008630
GO:0010212
GO:0010575
GO:0010628
GO:0012501
GO:0016567
GO:0016604
GO:0016740
GO:0019899
GO:0023052
GO:0030308
GO:0031398
GO:0031436
GO:0031625
GO:0032991
GO:0033147
GO:0036211
GO:0042802
GO:0043009
GO:0043226
GO:0043231
GO:0043232
GO:0043627
GO:0044027
GO:0044818
GO:0045717
GO:0045739
GO:0045766
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0051179
GO:0051726
GO:0051865
GO:0060816
GO:0070063
GO:0070531
GO:0070532
GO:0070533
GO:0071356
GO:0071479
GO:0071681
GO:0085020
GO:0140096
GO:0140110
GO:1902042
GO:1990391
GO:1990904
GO:2000378
Participates
as a component of
K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
Other forms of this molecule
phospho-BRCA1 [nucleoplasm]
BRCA1 [nucleoplasm]
BRCA1 [nucleoplasm]
phospho-BRCA1 [nucleoplasm]
phospho-BRCA1 [nucleoplasm]
Inferred From
K6PolyUb,p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K6-PolyUb [nucleoplasm]) at unknown position
Modification
K6polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
O-phospho-L-serine at 1387 (in Homo sapiens)
Coordinate
1387
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1423 (in Homo sapiens)
Coordinate
1423
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1457 (in Homo sapiens)
Coordinate
1457
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1524 (in Homo sapiens)
Coordinate
1524
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
OpenTargets
ENSG00000012048
Ensembl
ENSCAFG00845006070
,
ENSCAFP00845008432
,
ENSCAFT00845010804
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