Reactome | ASB6 [cytosol]

ASB6 [cytosol]

Stable Identifier

R-CFA-975412

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

ASB6, A0A8I3PNI5

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Class I MHC mediated antigen processing & presentation (Canis familiaris)
    - Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
      - Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
      - Polyubiquitination of substrate (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
        
        E3:Ub:substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
      - Release of E3 from polyubiquitinated substrate (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
      - Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
        
        E3:Ub:substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Canis familiaris)
        
        ASB family [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        ASB6 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PNI5

Gene Names

ASB6

Reference Genes

ENSEMBL:ENSCAFG00845023463.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845023463.1 ASB6

Other Identifiers

491299

Cfa.12165.1.A1_at

CfaAffx.30587.1.S1_at

CfaAffx.30588.1.S1_s_at

GO:0005515

GO:0023052

GO:0035556

Participates

as a member of

Inferred From

ASB6 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000148331

Ensembl

ENSCAFG00845023463, ENSCAFP00845032552, ENSCAFT00845041522

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