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KEAP1 [cytosol]
Stable Identifier
R-CFA-976038
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
KEAP1, A0A8I3PZ96
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
CUL3:RBX1 ubiquitinates KEAP1 (Canis familiaris)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Canis familiaris)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Canis familiaris)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Canis familiaris)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
Neddylation (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
NEDD8-CUL3:RBX1:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
NEDD8-CUL3:RBX1:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
RBX1:CUL3:BTB [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
KEAP1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PZ96
Gene Names
KEAP1
Reference Genes
BioGPS Gene:476713 KEAP1
ENSEMBL:ENSCAFG00845026598.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026598.1 KEAP1
KEGG Gene (Canis lupus familiaris):476713 KEAP1
Monarch:476713 KEAP1
NCBI Gene:476713 KEAP1
Reference Transcript
RefSeq:XM_005632897.2 KEAP1
RefSeq:XM_533917.5 KEAP1
Other Identifiers
476713
Cfa.3082.1.S1_s_at
GO:0001701
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0006351
GO:0006355
GO:0006511
GO:0006914
GO:0010506
GO:0016234
GO:0016567
GO:0030154
GO:0030163
GO:0030496
GO:0031463
GO:0032991
GO:0034451
GO:0034599
GO:0036211
GO:0042802
GO:0043226
GO:0045604
GO:0048856
GO:0060090
GO:0061629
GO:0071353
GO:0097718
GO:1990756
Participates
as a member of
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Canis familiaris)
BTB proteins [cytosol] (Canis familiaris)
as a component of
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Canis familiaris)
Other forms of this molecule
KEAP1 [cytosol]
KEAP1 [cytosol]
Inferred From
KEAP1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_005632954.1
,
XP_533917.2
OpenTargets
ENSG00000079999
Ensembl
ENSCAFP00845036847
,
ENSCAFG00845026598
,
ENSCAFT00845046964
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