Reactome | ADRM1 [nucleoplasm]

ADRM1 [nucleoplasm]

Stable Identifier

R-CFA-9918361

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

ADRM1, A0A8I3RZD9

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - G1/S DNA Damage Checkpoints (Canis familiaris)
    - p53-Independent G1/S DNA Damage Checkpoint (Canis familiaris)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        19S regulatory particle [nucleoplasm] (Canis familiaris)
        
        19S RP base [nucleoplasm] (Canis familiaris)
        
        ADRM1 [nucleoplasm] (Canis familiaris)
- Cell Cycle, Mitotic (Canis familiaris)
  - Mitotic G1 phase and G1/S transition (Canis familiaris)
    - G1/S Transition (Canis familiaris)
      - Cyclin E associated events during G1/S transition (Canis familiaris)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Canis familiaris)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        19S regulatory particle [nucleoplasm] (Canis familiaris)
        
        19S RP base [nucleoplasm] (Canis familiaris)
        
        ADRM1 [nucleoplasm] (Canis familiaris)
  - Regulation of mitotic cell cycle (Canis familiaris)
    - APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Canis familiaris)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        19S regulatory particle [nucleoplasm] (Canis familiaris)
        
        19S RP base [nucleoplasm] (Canis familiaris)
        
        ADRM1 [nucleoplasm] (Canis familiaris)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Canis familiaris)
        
        Degradation of multiubiquitinated Cdh1 (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        19S regulatory particle [nucleoplasm] (Canis familiaris)
        
        19S RP base [nucleoplasm] (Canis familiaris)
        
        ADRM1 [nucleoplasm] (Canis familiaris)
  - S Phase (Canis familiaris)
    - Cyclin A:Cdk2-associated events at S phase entry (Canis familiaris)
      - SCF(Skp2)-mediated degradation of p27/p21 (Canis familiaris)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        19S regulatory particle [nucleoplasm] (Canis familiaris)
        
        19S RP base [nucleoplasm] (Canis familiaris)
        
        ADRM1 [nucleoplasm] (Canis familiaris)

Cellular responses to stimuli (Canis familiaris)

- Cellular responses to stress (Canis familiaris)
  - Cellular response to chemical stress (Canis familiaris)
    - KEAP1-NFE2L2 pathway (Canis familiaris)
      - Nuclear events mediated by NFE2L2 (Canis familiaris)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Canis familiaris)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        19S regulatory particle [nucleoplasm] (Canis familiaris)
        
        19S RP base [nucleoplasm] (Canis familiaris)
        
        ADRM1 [nucleoplasm] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional regulation by RUNX2 (Canis familiaris)
      - Regulation of RUNX2 expression and activity (Canis familiaris)
        
        26S proteasome degrades PolyUb-RUNX2 (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        19S regulatory particle [nucleoplasm] (Canis familiaris)
        
        19S RP base [nucleoplasm] (Canis familiaris)
        
        ADRM1 [nucleoplasm] (Canis familiaris)
    - Transcriptional regulation by RUNX3 (Canis familiaris)
      - Regulation of RUNX3 expression and activity (Canis familiaris)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Canis familiaris)
        
        26S proteasome [nucleoplasm] (Canis familiaris)
        
        19S regulatory particle [nucleoplasm] (Canis familiaris)
        
        19S RP base [nucleoplasm] (Canis familiaris)
        
        ADRM1 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RZD9

Gene Names

ADRM1

Reference Genes

ENSEMBL:ENSCAFG00845016538.1

UCSC:A0A8I3RZD9 ADRM1

Other Identifiers

100855986

Cfa.7263.1.S1_s_at

GO:0000502

GO:0002020

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006368

GO:0008541

GO:0043248

GO:0061133

GO:0065003

GO:0070628

GO:0098772

Participates

as a component of

19S RP base [nucleoplasm] (Canis familiaris)

Other forms of this molecule

ADRM1 [cytosol]

Inferred From

ADRM1 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFP00845023115, ENSCAFG00845016538, ENSCAFT00845029415

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