Sialylation of Pre-Notch

Stable Identifier
R-CGR-2033005
Type
Reaction [transition]
Species
Cricetulus griseus
Compartment
Golgi lumen, Golgi membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Sialylation of Pre-Notch
Using Chinese hamster (Cricetulus griseus) ovary cells that express endogenous Notch1 but do not express endogenous Fringe proteins, Moloney et al. found after introduction of mouse Mfng that mature Notch1 had the Sia-alpha2,3-Gal-beta1,4-GlcNAc-beta1,3-fucitol tetrasaccharide attached to conserved serine and threonine residues in EGF repeats of Notch1 (Moloney et al. 2000). Sialyltransferases that could be involved in formation of this type of tetrasaccharide are St3gal3, St3gal4 and St3gal6 (Harduin-Lepers et al. 2001).
Literature References
PubMed ID Title Journal Year
11530204 The human sialyltransferase family

Vallejo-Ruiz, V, Harduin-Lepers, A, Delannoy, P, Samyn-Petit, B, Krzewinski-Recchi, MA, Julien, S

Biochimie 2001
10935626 Fringe is a glycosyltransferase that modifies Notch

Shao, L, Wang, Y, Johnston, SH, Irvine, KD, Stanley, P, Haltiwanger, RS, Moloney, DJ, Wilson, R, Chen, J, Vogt, TF, Panin, VM

Nature 2000
Participants
Input
Output
Catalyst Activity

sialyltransferase activity of St3gal3/4/6 [Golgi membrane]

Physical Entity
St3gal3/4/6 [Golgi membrane] (Cricetulus griseus)
Activity
sialyltransferase activity (GO:0008373)
Orthologous Events
Sialylation of Pre-NOTCH (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2012-01-08)
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