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pp1a-nsp1 [cytosol]
Stable Identifier
R-COV-9678243
Type
Protein [EntityWithAccessionedSequence]
Species
Human SARS coronavirus
Compartment
cytosol
Synonyms
nsp1, 1a (1-180), Host translation inhibitor nsp1, Non-structural protein 1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 nsp1 binds to PPIase (Homo sapiens)
PPIase:nsp1 [cytosol] (Homo sapiens)
nsp1 [cytosol] (Human SARS coronavirus)
pp1a-nsp1 [cytosol] (Human SARS coronavirus)
nsp1 [cytosol] (Human SARS coronavirus)
pp1a-nsp1 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 nsp1 binds to RCAN3 (Homo sapiens)
RCAN3:nsp1 [cytosol] (Homo sapiens)
nsp1 [cytosol] (Human SARS coronavirus)
pp1a-nsp1 [cytosol] (Human SARS coronavirus)
nsp1 [cytosol] (Human SARS coronavirus)
pp1a-nsp1 [cytosol] (Human SARS coronavirus)
SARS-CoV-1 modulates host translation machinery (Homo sapiens)
SARS-CoV-1 nsp1 binds to 40S ribosomal subunit (Homo sapiens)
40S ribosomal complex:nsp1 [cytosol] (Homo sapiens)
nsp1 [cytosol] (Human SARS coronavirus)
pp1a-nsp1 [cytosol] (Human SARS coronavirus)
nsp1 [cytosol] (Human SARS coronavirus)
pp1a-nsp1 [cytosol] (Human SARS coronavirus)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Maturation of replicase proteins (Homo sapiens)
nsp1-4 cleaves itself (Homo sapiens)
nsp1 [cytosol] (Human SARS coronavirus)
pp1a-nsp1 [cytosol] (Human SARS coronavirus)
nsp3 cleaves nsp1-4 (Homo sapiens)
nsp1 [cytosol] (Human SARS coronavirus)
pp1a-nsp1 [cytosol] (Human SARS coronavirus)
External Reference Information
External Reference
UniProt:P0C6U8 1a
Gene Names
1a
Chain
chain:1-4382, chain:1-180, chain:181-818, chain:819-2740, chain:2741-3240, chain:3241-3546, chain:3547-3836, chain:3837-3919, chain:3920-4117, chain:4118-4230, chain:4231-4369, chain:4370-4382
Participates
as a member of
nsp1 [cytosol] (Human SARS coronavirus)
Other forms of this molecule
pp1a-nsp11 [cytosol]
pp1a-nsp9 [cytosol]
pp1a-nsp6 [endoplasmic reticulum membrane]
N-glycan pp1a-nsp4 [endoplasmic reticulum membrane]
N-glycan pp1a-nsp3 [endoplasmic reticulum membrane]
pp1a-nsp4 [cytosol]
pp1a-nsp3 [cytosol]
N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane]
pp1a-nsp6-11 [cytosol]
pp1a-nsp5 [cytosol]
pp1a-nsp2 [cytosol]
pp1a-nsp3-4 [cytosol]
pp1a-nsp1-4 [cytosol]
pp1a-nsp6 [double membrane vesicle viral factory outer membrane]
pp1a-nsp4 [double membrane vesicle viral factory outer membrane]
pp1a-nsp3 [double membrane vesicle viral factory outer membrane]
pp1a-nsp7 [cytosol]
pp1a-nsp10 [cytosol]
pp1a-nsp8 [cytosol]
pp1a [cytosol]
Disease
Name
Identifier
Synonyms
severe acute respiratory syndrome
DOID:2945
SARS-CoV infection, SARS
Cross References
ZINC - Investigational
R1A_CVHSA
ZINC - Metabolites
R1A_CVHSA
IntEnz
3.4.22.69
ZINC - Substances
R1A_CVHSA
ZINC - Biogenic
R1A_CVHSA
ZINC target
P0C6U8
ZINC - Predictions - Purchasable
R1A_CVHSA
PDB
7VLO
,
1UJ1
,
3TNS
,
7RC1
,
4OVZ
,
3F9H
,
3VB3
,
4HI3
,
2H2Z
,
3SNC
,
2FYG
,
3TIU
,
3AW1
,
7YGQ
,
2A5K
,
1QZ8
,
3E91
,
2GRI
,
7WQI
,
6NUS
,
2ACF
,
1UW7
,
2A5A
,
2C3S
,
6XHO
,
5Y3E
,
2HOB
,
2KQV
,
2GT8
,
7LMG
,
5F22
,
2GDT
,
3VB4
,
7K0G
,
7DQZ
,
2FE8
,
7LFU
,
7XAX
,
2GA6
,
3IWM
,
2ZU5
,
8HUS
,
3R24
,
7OPL
,
2ZU4
,
2OP9
,
4MM3
,
3F9F
,
7EO8
,
7ZQW
,
3M3S
,
1UK2
,
3SNA
,
2GZ8
,
2FAV
,
2AMD
,
2PWX
,
1Z1I
,
2W2G
,
7END
,
3VB7
,
3EA7
,
7LMH
,
2KYS
,
1YSY
,
7K0H
,
3AVZ
,
3VB5
,
3ATW
,
6LNY
,
6Y7M
,
2Z3C
,
2WCT
,
7LFV
,
7FA1
,
4OW0
,
2A5I
,
2D2D
,
1Z1J
,
2IDY
,
3F9E
,
3SND
,
3EA8
,
2Z3E
,
2BX3
,
1UK3
,
3M3T
,
2GTB
,
1Q2W
,
6XHL
,
3TNT
,
2GT7
,
2GX4
,
7LMI
,
3V3M
,
3FZD
,
3F9G
,
1WOF
,
3VB6
,
6YXJ
,
7FAC
,
2AHM
,
2Z3D
,
6LO0
,
4MDS
,
2DUC
,
2LIZ
,
3EAJ
,
2BX4
,
1UK4
,
2AMQ
,
3AW0
,
3SZN
,
3SNE
,
2GZ9
,
2KQW
,
3EA9
,
5Y3Q
,
3SNB
,
3SN8
,
3TIT
,
6W2A
,
2G9T
,
2HSX
,
3M3V
,
6NUR
,
3MJ5
,
2ALV
,
4M0W
,
6XHN
,
3EE7
,
2GZ7
,
7LMJ
,
2KAF
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0C6U8 1a
20
pp1a-nsp11 [cytosol]
(R-COV-9678271)
pp1a-nsp9 [cytosol]
(R-COV-9678273)
pp1a-nsp6 [endoplasmic reticulum membrane]
(R-COV-9678265)
N-glycan pp1a-nsp4 [endoplasmic reticulum membrane]
(R-COV-9684271)
N-glycan pp1a-nsp3 [endoplasmic reticulum membrane]
(R-COV-9678246)
pp1a-nsp4 [cytosol]
(R-COV-9684342)
pp1a-nsp3 [cytosol]
(R-COV-9684257)
N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane]
(R-COV-9684267)
pp1a-nsp6-11 [cytosol]
(R-COV-9684354)
pp1a-nsp5 [cytosol]
(R-COV-9678259)
pp1a-nsp2 [cytosol]
(R-COV-9678250)
pp1a-nsp3-4 [cytosol]
(R-COV-9684263)
pp1a-nsp1 [cytosol]
(R-COV-9678243)
pp1a-nsp1-4 [cytosol]
(R-COV-9684311)
pp1a-nsp6 [double membrane vesicle viral factory outer membrane]
(R-COV-9686007)
pp1a-nsp4 [double membrane vesicle viral factory outer membrane]
(R-COV-9685995)
pp1a-nsp3 [double membrane vesicle viral factory outer membrane]
(R-COV-9686004)
pp1a-nsp7 [cytosol]
(R-COV-9678266)
pp1a-nsp10 [cytosol]
(R-COV-9678272)
pp1a-nsp8 [cytosol]
(R-COV-9678275)
0.558
6
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