Reactome | pp1ab-nsp14 [cytosol]

pp1ab-nsp14 [cytosol]

Stable Identifier

R-COV-9678285

Type

Protein [EntityWithAccessionedSequence]

Species

Human SARS coronavirus

Compartment

cytosol

Synonyms

Guanine-N7 methyltransferase, rep (5903–6429)

Locations in the PathwayBrowser for interactor UniProt:O75348 ATP6V1G1

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External Reference Information

External Reference

UniProt:P0C6X7 rep

Gene Names

rep, 1a-1b

Chain

chain:1-180, chain:181-818, chain:819-2740, chain:2741-3240, chain:3241-3546, chain:3547-3836, chain:3837-3919, chain:3920-4117, chain:4118-4230, chain:4231-4369, chain:4370-5301, chain:5302-5902, chain:5903-6429, chain:6430-6775, chain:6776-7073

Reference Genes

BioGPS Gene:1489680 REP

KEGG:vg:1489680 REP

Monarch:1489680 REP

NCBI Gene:1489680 REP

UCSC:P0C6X7 REP

Reference Transcript

RefSeq:NC_004718.3 Q6S8E0

Participates

as an input of

nsp14 binds nsp10 (Homo sapiens)

as an output of

3CLp cleaves pp1ab (Homo sapiens)

as a component of

nsp10:nsp14 [cytosol] (Human SARS coronavirus)

Other forms of this molecule

pp1ab-nsp15 [cytosol]

pp1ab-nsp10 [cytosol]

pp1ab-nsp8 [cytosol]

pp1ab-nsp7 [cytosol]

pp1ab-nsp12 [cytosol]

pp1ab-nsp13 [cytosol]

pp1ab-nsp16 [cytosol]

pp1ab-nsp3 [double membrane vesicle viral factory outer membrane]

pp1ab-nsp4 [double membrane vesicle viral factory outer membrane]

pp1ab-nsp6 [double membrane vesicle viral factory outer membrane]

pp1ab [cytosol]

pp1ab-nsp1-4 [cytosol]

pp1ab-nsp1 [cytosol]

pp1ab-nsp3-4 [cytosol]

pp1ab-nsp2 [cytosol]

pp1ab-nsp5 [cytosol]

pp1ab-nsp6 [endoplasmic reticulum membrane]

pp1ab-nsp9 [cytosol]

N-glycan pp1ab-nsp3-4 [endoplasmic reticulum membrane]

pp1ab-nsp3 [cytosol]

pp1ab-nsp4 [cytosol]

N-glycan pp1ab-nsp3 [endoplasmic reticulum membrane]

N-glycan pp1ab-nsp4 [endoplasmic reticulum membrane]

Inferred To

pp1ab-nsp14 [cytosol] (Severe acute respiratory syndrome coronavirus 2)

Disease

Name	Identifier	Synonyms
severe acute respiratory syndrome	DOID:2945	SARS-CoV infection, SARS

Cross References

RefSeq

NP_828849.2

ZINC - Metabolites

R1AB_CVHSA

IntEnz

2.7.7.50, 3.4.22.69

ZINC - Substances

R1AB_CVHSA

ZINC - Biogenic

R1AB_CVHSA

ZINC target

P0C6X7

ZINC - Predictions - Purchasable

R1AB_CVHSA

PDB

3E9S, 2H85, 2G9T, 2AMQ, 2GT7, 2A5I, 5E6J, 2VJ1, 1WOF, 2ACF, 2Z9K, 5C5N, 5C8U, 5B6O, 2RNK, 2BX3, 4TWY, 2GTB, 5F22, 2XYV, 2Z3E, 2GZ8, 8CB3, 5C5O, 1Q2W, 2D2D, 2OP9, 2Z3C, 2GZ9, 2GT8, 2V6N, 4WY3, 2A5K, 1Z1I, 7LCP, 1UK2, 2Z9L, 2PWX, 3D62, 2FE8, 2AHM, 5C8T, 2K7X, 2IDY, 2HSX, 1YSY, 2JZE, 6W79, 2Q6G, 3EBN, 3R24, 2Z3D, 2GRI, 1UJ1, 6NUR, 2Z94, 2XYQ, 2RHB, 7LCQ, 2QIQ, 1UK3, 2Z9G, 2FYG, 6JYT, 6LNQ, 4ZUH, 2K87, 2H2Z, 5NFY, 2JZD, 2A5A, 2BX4, 2GZ7, 2AMD, 8C0G, 5N5O, 6NUS, 1Z1J, 2XYR, 2GX4, 1UK4, 2FAV, 2Z9J, 2DUC, 2QCY, 5C8S, 2QC2, 2C3S, 2GA6, 2JZF, 2OZK, 4TWW, 2ALV, 1QZ8, 1UW7, 5N19, 2HOB, 2GDT, 6WCO

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0C6X7 rep	20	pp1ab-nsp15 [cytosol] (R-COV-9678288) pp1ab-nsp10 [cytosol] (R-COV-9682216) pp1ab-nsp14 [cytosol] (R-COV-9678285) pp1ab-nsp8 [cytosol] (R-COV-9682242) pp1ab-nsp7 [cytosol] (R-COV-9682244) pp1ab-nsp12 [cytosol] (R-COV-9678280) pp1ab-nsp13 [cytosol] (R-COV-9678281) pp1ab-nsp16 [cytosol] (R-COV-9678289) pp1ab-nsp3 [double membrane vesicle viral factory outer membrane] (R-COV-9685989) pp1ab-nsp4 [double membrane vesicle viral factory outer membrane] (R-COV-9686029) pp1ab-nsp6 [double membrane vesicle viral factory outer membrane] (R-COV-9685986) pp1ab [cytosol] (R-COV-9684355) pp1ab-nsp1-4 [cytosol] (R-COV-9684861) pp1ab-nsp1 [cytosol] (R-COV-9682211) pp1ab-nsp3-4 [cytosol] (R-COV-9684864) pp1ab-nsp2 [cytosol] (R-COV-9682221) pp1ab-nsp5 [cytosol] (R-COV-9682196) pp1ab-nsp6 [endoplasmic reticulum membrane] (R-COV-9682233) pp1ab-nsp9 [cytosol] (R-COV-9682232) N-glycan pp1ab-nsp3-4 [endoplasmic reticulum membrane] (R-COV-9684874)	0.676	3
UniProt:O75348 ATP6V1G1	1	ATP6V1G1 [cytosol] (R-HSA-912578)	0.656	5

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