Reactome | nascent M [endoplasmic reticulum lumen]

nascent M [endoplasmic reticulum lumen]

Stable Identifier

R-COV-9683586

Type

Protein [EntityWithAccessionedSequence]

Species

Human SARS coronavirus

Compartment

endoplasmic reticulum lumen

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P59596 M

Gene Names

M, 5

Chain

chain:1-221

Reference Genes

BioGPS Gene:1489672 M

Monarch:1489672 M

NCBI Gene:1489672 M

Reference Transcript

RefSeq:NC_004718.3 M

Participates

as an input of

as an output of

mRNA5 is translated to protein M (Homo sapiens)

Other forms of this molecule

M [plasma membrane]

M [Golgi membrane]

N-glycan M [endoplasmic reticulum membrane]

N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]

M [endoplasmic reticulum-Golgi intermediate compartment membrane]

M [endocytic vesicle membrane]

N-glycan M [endocytic vesicle membrane]

M [virion membrane]

N-glycan M [virion membrane]

Inferred To

nascent M [endoplasmic reticulum lumen] (Severe acute respiratory syndrome coronavirus 2)

Disease

Name	Identifier	Synonyms
severe acute respiratory syndrome	DOID:2945	SARS-CoV infection, SARS

Cross References

RefSeq

NP_828855.1

PDB

3I6K, 3TO2, 3I6G

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.907	19
UniProt:P59637 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9683652) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9683767) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683626) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683597) nascent E [endoplasmic reticulum lumen] (R-COV-9683684) Ub-3xPalmC-E [Golgi membrane] (R-COV-9683694) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698721) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698722) Ub-3xPalmC-E [virion membrane] (R-COV-9698716)	0.71	6
UniProt:Q9UHD2 TBK1	4	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267)	0.702	5
UniProt:O95786 DDX58	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.589	4
UniProt:P59632 3a	10	O-glycosyl 3a [lysosomal membrane] (R-COV-9692650) O-glycosyl 3a [cytosol] (R-COV-9686279) O-glycosyl 3a [extracellular region] (R-COV-9685941) O-glycosyl 3a [plasma membrane] (R-COV-9685962) 3a [endoplasmic reticulum lumen] (R-COV-9683715) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683691) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683709) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683640) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9686708) O-glycosyl 3a [virion membrane] (R-COV-9686228)	0.573	2
UniProt:P61769 B2M	11	B2M(21-119) [early endosome membrane] (R-HSA-182298) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [plasma membrane] (R-HSA-167743)	0.524	2
UniProt:P59594 S	12	nascent Spike [endoplasmic reticulum lumen] (R-COV-9682868) N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683594) trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683716) trimmed N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683608) trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen] (R-COV-9683638) trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683657) complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683617) complex N-glycan-PALM-Spike [virion membrane] (R-COV-9685469) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9686730) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9686693) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9686706) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9686724)	0.463	2

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