Reactome | N-glycan M [endocytic vesicle membrane]

N-glycan M [endocytic vesicle membrane]

Stable Identifier

R-COV-9686698

Type

Protein [EntityWithAccessionedSequence]

Species

Human SARS coronavirus

Compartment

endocytic vesicle membrane

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        Attachment and Entry (Homo sapiens)
        
        Fusion and Release of SARS-CoV-1 Nucleocapsid (Homo sapiens)
        
        S1:S2:M:E: 7a:O-glycosyl 3a tetramer [endocytic vesicle membrane] (Human SARS coronavirus)
        
        S1:S2:M lattice:E protein [endocytic vesicle membrane] (Human SARS coronavirus)
        
        M lattice [endocytic vesicle membrane] (Human SARS coronavirus)
        
        N-glycan M [endocytic vesicle membrane] (Human SARS coronavirus)

External Reference Information

External Reference

UniProt:P59596 M

Gene Names

M, 5

Chain

chain:1-221

Reference Genes

UCSC:P59596 M

Participates

as a component of

M lattice [endocytic vesicle membrane] (Human SARS coronavirus)

Other forms of this molecule

M [plasma membrane]

M [Golgi membrane]

N-glycan M [endoplasmic reticulum membrane]

nascent M [endoplasmic reticulum lumen]

N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]

M [endoplasmic reticulum-Golgi intermediate compartment membrane]

M [endocytic vesicle membrane]

M [virion membrane]

N-glycan M [virion membrane]

Inferred To

N-glycan M [endocytic vesicle membrane] (Severe acute respiratory syndrome coronavirus 2)

Modified Residues

Name

N-glycosylated residue at 4

Coordinate

PsiMod Name

N-glycosylated residue

PsiMod Definition

A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond.

Disease

Name	Identifier	Synonyms
severe acute respiratory syndrome	DOID:2945	SARS-CoV infection, SARS

Cross References

GlyGen

P59596

PDB

3I6K, 3TO2, 3I6G

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.907	19
UniProt:P59637 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9683652) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9683767) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683626) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9683597) nascent E [endoplasmic reticulum lumen] (R-COV-9683684) Ub-3xPalmC-E [Golgi membrane] (R-COV-9683694) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698721) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698722) Ub-3xPalmC-E [virion membrane] (R-COV-9698716)	0.71	6
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.702	5
UniProt:O95786 RIGI	4	DDX58 [cytosol] (R-HSA-168917) K63polyUb-DDX58 [cytosol] (R-HSA-918191) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) PolyUb-DDX58 [cytosol] (R-HSA-6782770)	0.589	4
UniProt:P59632 3a	10	O-glycosyl 3a [lysosomal membrane] (R-COV-9692650) O-glycosyl 3a [cytosol] (R-COV-9686279) O-glycosyl 3a [extracellular region] (R-COV-9685941) O-glycosyl 3a [plasma membrane] (R-COV-9685962) 3a [endoplasmic reticulum lumen] (R-COV-9683715) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683691) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683709) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683640) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9686708) O-glycosyl 3a [virion membrane] (R-COV-9686228)	0.573	2
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.524	2
UniProt:P59594 S	12	complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9686724) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9686706) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9686693) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9686730) complex N-glycan-PALM-Spike [virion membrane] (R-COV-9685469) complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683617) trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9683657) trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen] (R-COV-9683638) trimmed N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683608) trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683716) N-glycan Spike [endoplasmic reticulum lumen] (R-COV-9683594) nascent Spike [endoplasmic reticulum lumen] (R-COV-9682868)	0.463	2

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