Reactome | 6 [endoplasmic reticulum membrane]

6 [endoplasmic reticulum membrane]

Stable Identifier

R-COV-9727295

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

endoplasmic reticulum membrane

Synonyms

ORF6 protein

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P0DTC6 6

Gene Names

Chain

chain:1-61

Reference Genes

KEGG:vg:43740572 6

UCSC:P0DTC6 6

Participates

as an input of

6 localizes to the nuclear envelope (Homo sapiens)

as an output of

mRNA6 is translated to protein 6 (Homo sapiens)

Other forms of this molecule

6 [nuclear envelope]

6 [cytosol]

6 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

PDB

7VPH, 7F60

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78406 RAE1	1	RAE1 [nuclear envelope] (R-HSA-157718)	0.928	11
UniProt:P52948 NUP98			0.912	11
UniProt:Q96HR9 REEP6			0.666	4
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.601	4
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.589	2
UniProt:Q15041 AR6P1			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:O75360 PROP1			0.556	3
UniProt:Q9NYU1 UGGT2	1	UGGT2 [endoplasmic reticulum lumen] (R-HSA-548863)	0.556	3
UniProt:O95870 ABHGA			0.556	3
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.553	2
UniProt:O75150 RNF40	1	RNF40 [nucleoplasm] (R-HSA-5689015)	0.547	2
UniProt:P30622 CLIP1	3	CLIP1 [cytosol] (R-HSA-377732) CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane] (R-HSA-9842572) CLIP1(1-1083)-p-6Y LTK(488-864) fusion [plasma membrane] (R-HSA-9842573)	0.547	2
UniProt:Q7Z3E2 CC186			0.547	2
UniProt:Q14571 ITPR2	2	ITPR2 [platelet dense tubular network membrane] (R-HSA-418281) ITPR2 [endoplasmic reticulum membrane] (R-HSA-3006467)	0.527	2
UniProt:Q14573 ITPR3	2	ITPR3 [endoplasmic reticulum membrane] (R-HSA-169690) ITPR3 [platelet dense tubular network membrane] (R-HSA-418283)	0.527	2
UniProt:Q9NZJ7 MTCH1			0.527	2
UniProt:P0DTD1-PRO_0000449632 REP			0.488	2
UniProt:P0DTD1-PRO_0000449624 REP			0.488	2
UniProt:P0DTD1-PRO_0000449625 REP			0.488	2
UniProt:P28290 ITPI2			0.482	2
UniProt:O43707 ACTN4	3	ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729) ACTN4 [cytosol] (R-HSA-390558)	0.482	2

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