Reactome | O-glycosyl 3a [endolysosome membrane]

O-glycosyl 3a [endolysosome membrane]

Stable Identifier

R-COV-9754541

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

endolysosome membrane

Synonyms

P0DTC3

Locations in the PathwayBrowser

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General

SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

Literature References

PubMed ID	Title	Journal	Year
16474139	Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M Oostra, M, de Haan, CA, de Groot, RJ, Rottier, PJ	J. Virol.	2006

External Reference Information

External Reference

UniProt:P0DTC3 3a

Gene Names

Chain

chain:1-275

Reference Genes

UCSC:P0DTC3 3a

Participates

as a component of

O-glycosyl 3a tetramer [endolysosome membrane] (Severe acute respiratory syndrome coronavirus 2)

Other forms of this molecule

O-glycosyl 3a [virion membrane]

O-glycosyl 3a [endocytic vesicle membrane]

O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]

GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]

3a [endoplasmic reticulum-Golgi intermediate compartment]

3a [endoplasmic reticulum lumen]

O-glycosyl 3a [plasma membrane]

O-glycosyl 3a [extracellular region]

Inferred From

O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)

Modified Residues

Name

O-glycosyl-L-threonine at unknown position

PsiMod Name

O-glycosyl-L-threonine

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine.

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

Mondo

0100096

GlyGen

P0DTC3

PDB

8EQJ, 8T5Q, 8T5P, 8EQT, 6XDC, 7KJR, 8EQU

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JC1 VPS39	1	VPS39 [endosome membrane] (R-HSA-2197806)	0.956	19
UniProt:Q96S66 CLCC1			0.875	9
UniProt:Q9H270 VPS11	1	VPS11 [endosome membrane] (R-HSA-2197802)	0.823	7
UniProt:P09601 HMOX1	4	HMOX1 [cytosol] (R-HSA-9609901) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [nucleoplasm] (R-HSA-9708567)	0.738	4
UniProt:Q9Y673 ALG5	1	ALG5 [endoplasmic reticulum membrane] (R-HSA-532211)	0.738	4
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.716	4
UniProt:P49754 VPS41	1	VPS41 [endosome membrane] (R-HSA-2197800)	0.695	4
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.659	3
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.659	3
UniProt:Q8N6S5 AR6P6			0.643	3
UniProt:Q8IWR1 TRI59			0.643	3
UniProt:Q01518 CAP1	3	CAP1 [azurophil granule lumen] (R-HSA-6798752) CAP1 [extracellular region] (R-HSA-350746) CAP1 [cytosol] (R-HSA-350758)	0.613	3
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.602	4
UniProt:P51809 VAMP7	6	VAMP7 [plasma membrane] (R-HSA-376361) VAMP7 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869135) VAMP7 [late endosome membrane] (R-HSA-2193120) VAMP7 [lysosomal membrane] (R-HSA-376342) VAMP7 [Golgi membrane] (R-HSA-266197) VAMP7 [cytoplasmic vesicle membrane] (R-HSA-376336)	0.602	4
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.602	6
UniProt:Q07157 TJP1	6	TJP1 [cytosol] (R-HSA-532659) TJP1 [Golgi-associated vesicle membrane] (R-HSA-3209843) TJP1 [plasma membrane] (R-HSA-3209845) TJP1 (?-?) [plasma membrane] (R-HSA-3209844) TJP1 [cell junction] (R-HSA-8936023) TJP1 [nucleoplasm] (R-HSA-9921246)	0.589	2
UniProt:P49796-4 RGS3			0.589	2
UniProt:Q86UT5-2 NHERF4			0.589	2
UniProt:Q5T2W1 NHRF3			0.589	3
UniProt:Q8TEW8 PAR3L			0.589	2
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.547	2
UniProt:Q8NBS9 TXNDC5	4	TXNDC5 [Golgi lumen] (R-HSA-434325) TXNDC5 [lysosomal lumen] (R-HSA-429813) TXNDC5 [extracellular region] (R-HSA-6806246) TXNDC5 [azurophil granule lumen] (R-HSA-6799367)	0.547	2
UniProt:Q92545 TM131			0.547	2
UniProt:Q9H0V9 LMAN2L	3	LMAN2L [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689834) LMAN2L [ER to Golgi transport vesicle membrane] (R-HSA-5689832) LMAN2L [endoplasmic reticulum membrane] (R-HSA-5689469)	0.547	2
UniProt:Q96HE7 ERO1A	1	ERO1L [endoplasmic reticulum lumen] (R-HSA-265076)	0.547	2
UniProt:P07205 PGK2	1	PGK2 [cytosol] (R-HSA-6807622)	0.547	2
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.547	2
UniProt:O75976 CPD	3	CPD [Golgi membrane] (R-HSA-432675) CPD [cytoplasmic vesicle membrane] (R-HSA-432671) CPD [plasma membrane] (R-HSA-9715182)	0.527	2
UniProt:P30519 HMOX2	3	HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [plasma membrane] (R-HSA-6799676)	0.527	2
UniProt:Q9Y617 PSAT1	1	PXLP-K200-PSAT1 [cytosol] (R-HSA-977330)	0.527	2
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.527	2
UniProt:P51153 RAB13	4	GGC-RAB13 [cytoplasmic vesicle membrane] (R-HSA-1445110) GGC-RAB13 [cell junction] (R-HSA-8876591) GGC-RAB13 [cytosol] (R-HSA-8873767) RAB13 [cytosol] (R-HSA-8873674)	0.527	2
UniProt:Q9Y4P3 TBL2			0.527	2
UniProt:Q9NRX4 PHP14			0.527	2
UniProt:P61106 RAB14	7	GGC-RAB14 [cytoplasmic vesicle membrane] (R-HSA-1445086) GGC-RAB14 [recycling endosome membrane] (R-HSA-8876593) GGC-RAB14 [cytosol] (R-HSA-8873763) RAB14 [cytosol] (R-HSA-8873701) RAB14 [early endosome membrane] (R-HSA-8871372) RAB14 [plasma membrane] (R-HSA-6806438) RAB14 [tertiary granule membrane] (R-HSA-6800407)	0.527	2
UniProt:Q9UNN8 PROCR	2	PROCR(18-?) [extracellular region] (R-HSA-5610109) PROCR [plasma membrane] (R-HSA-5591027)	0.527	2
UniProt:P04439 HLA-A	9	HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983100) HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane] (R-HSA-983376) HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane] (R-HSA-197642) HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983347) HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane] (R-HSA-1236826) HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane] (R-HSA-8863889) HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236740) HLA-A A-3 [endoplasmic reticulum membrane] (R-HSA-8943090) K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943073)	0.527	2
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.527	2
UniProt:P0DTD8 NS7B			0.519	3
UniProt:Q8NAF0 ZN579			0.499	2
UniProt:P0DTD1-PRO_0000449632 REP			0.488	2
UniProt:Q8NHV4 NEDD1	1	NEDD1 [cytosol] (R-HSA-379267)	0.483	2
UniProt:Q9P253 VPS18	1	VPS18 [endosome membrane] (R-HSA-2197799)	0.483	2
UniProt:Q9H269 VPS16	1	VPS16 [endosome membrane] (R-HSA-2197803)	0.483	2
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.483	2
UniProt:Q9H3K2 GHITM			0.482	2
UniProt:P42765 ACAA2	1	ACAA2 [mitochondrial matrix] (R-HSA-8874752)	0.482	2
UniProt:Q96GS4 BORC6			0.463	2
UniProt:Q9GZU1 MCOLN1	2	MCOLN1 [plasma membrane] (R-HSA-3211764) MCOLN1 [endosome membrane] (R-HSA-917803)	0.463	2

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