S(686-815) [plasma membrane]

Stable Identifier
R-COV-9770188
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
Synonyms
P0DTC2
Locations in the PathwayBrowser
General

SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

External Reference Information
External Reference
Gene Names
S, 2
Chain
signal peptide:1-13, chain:14-1273, chain:14-685, chain:686-1273, chain:816-1273
Reference Transcript
Participates
Other forms of this molecule
Modified Residues
Name
palmitoylated-L-cysteine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801
Coordinate
801
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 709
Coordinate
709
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 717
Coordinate
717
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
PDB
7SPP, 7PQZ, 7V7A, 7KKL, 7DWY, 7KMS, 7PS6, 7SJS, 7TP2, 7SBT, 7SXS, 7CHS, 7WUH, 7VMU, 7S0B, 7NS6, 7W9F, 7V7P, 7L09, 7CWL, 7SY8, 7JJC, 7CT5, 7D03, 7FDH, 7NXA, 7LXX, 7JZL, 7K8W, 7EFR, 7EY0, 7FCE, 7DMU, 6XCN, 6WPS, 7TLA, 7L06, 7A92, 7VYR, 7V82, 7F7E, 7RTR, 7MZI, 7EJ4, 7EKH, 7CZU, 7N1W, 7LAB, 7R10, 6LXT, 7TF1, 7N1B, 6ZGI, 7LYO, 7NT9, 7SXU, 7DWZ, 7VNC, 7TP4, 7V7R, 7PS7, 7KN3, 7SC1, 7R8L, 7KS9, 7KE4, 7PR0, 7S0C, 7CAH, 7DHX, 7CWN, 7E3J, 7NXB, 7FDI, 7LXY, 6YM0, 7V84, 7JZN, 7K8Y, 7MJK, 6ZOW, 7E7D, 7C8J, 7DX8, 6WPT, 7TLB, 7VX4, 7C53, 7ND8, 7LC8, 7EY4, 7CAB, 7EJ5, 7WVN, 7KFV, 7N1X, 7LS9, 7V7E, 7CN4, 7C01, 7Z0Y, 7BEH, 7LYP, 7MZK, 7TF3, 6ZB4, 7R19, 7CHF, 7FAE, 7V76, 6ZP2, 6ZWV, 7KDI, 7TOY, 7OD3, 7L58, 7BEP, 7M8T, 7CZR, 7X08, 7V26, 7L7D, 7KE9, 7V7N, 7PS4, 7Q9G, 7MY8, 7DEO, 7LQV, 7EDI, 7RR0, 7A5S, 7MFU, 7LWO, 7JVC, 7K8S, 7SY2, 7KJ3, 7OR9, 7ND5, 7E9P, 7KE8, 7LQ7, 7DDN, 7OAY, 7KQB, 7EKF, 7M42, 7BNN, 6ZGE, 7QO9, 7MJG, 7OLZ, 6XC7, 7VXI, 7MLZ, 7V78, 7DWX, 7WBL, 7KKK, 7ODL, 7KDJ, 7LAA, 7Q9I, 7SBR, 6ZP5, 7CHO, 7SXR, 7CZT, 7SPO, 7KML, 7WD7, 6LVN, 7W9C, 7TP0, 7PS5, 7E39, 7JWY, 7NX9, 7SY6, 7M6D, 7D00, 7TIK, 7DET, 7KJ5, 7LXW, 7E23, 7JW0, 7SY4, 7M53, 6XCM, 7K8U, 7KQE, 7R0Z, 7ND7, 7NEH, 6YZ5, 7ORA, 7L02, 7A91, 7EAN, 7LWP, 7EKG, 6ZXN, 7MZG, 7MM0, 7RTD, 7N0H, 7TEZ, 6ZGG, 7VXM, 7LWM, 7SOC, 7D4G, 7SXZ, 7TPE, 6ZDH, 7LM8, 7V7V, 7TGY, 7WK3, 7LWV, 7A98, 7EKC, 7K45, 7TN0, 7OAQ, 7TEW, 7JVA, 6X6P, 7MW5, 7E8M, 7DD8, 6XM4, 7V8B, 7WEV, 7N4L, 7CDI, 7V89, 7KMB, 7NDB, 7BEL, 7K43, 7LJR, 7R16, 7L4Z, 7EK6, 7Z1C, 7M7B, 7FET, 7CYP, 7CH4, 7KGJ, 7RAL, 7LWK, 7NAB, 7KNE, 7EDF, 7A25, 7LWN, 7DDD, 7SY1, 7BWJ, 7V7Z, 7NX6, 7SOD, 7DX4, 7KJ2, 7THE, 7E9O, 7OAU, 7RKV, 7MF1, 7LYL, 7LWW, 7K9K, 7EKE, 7WK8, 7NDD, 7N5H, 6XM5, 7TEX, 6X79, 7ME7, 6ZER, 7CHB, 7A29, 7M8J, 7BEM, 7FG3, 7VXD, 7NDC, 7CZP, 7TOV, 7N9T, 7Z1D, 7D6I, 7LO4, 7R17, 7N4M, 7RAQ, 7V7H, 6XRA, 7SBO, 7KNH, 7Q0I, 7KGK, 7TPH, 7KDG, 7W98, 7NTC, 7MY2, 7RZS, 7N8I, 7DX0, 7SOA, 7VNE, 7M6H, 7NTA, 7V7S, 7TP8, 7R8M, 7KE6, 6XF5, 6X2A, 7JV2, 7JMP, 7A96, 7TGW, 7TBF, 7S0D, 7EB4, 7FDK, 7CWS, 7N4I, 7V86, 7MJL, 7P3E, 7K8Z, 7TAT, 7KXJ, 7T9J, 6ZOX, 6XKL, 7C8V, 7E7Y, 7P77, 6X29, 7EJY, 7TLC, 7DX9, 7EY5, 6Z97, 7DJZ, 7WVO, 7N1Y, 7KSG, 7KN5, 7KFW, 7CZX, 7KLH, 7Z1A, 7LSS, 7LYQ, 7V7F, 7LWI, 7DZW, 7B17, 7LDJ, 7RZT, 7M6I, 7SOB, 7TPA, 7SXX, 7B3O, 7KE7, 6ZDG, 7TCA, 7R8N, 7DK0, 7TGX, 7E8C, 7S0E, 7CAN, 7OAP, 7A97, 7EB5, 6XC2, 7KZB, 6XM0, 7WK2, 7JMW, 7MW3, 7CWU, 7MJM, 7VXA, 7KXK, 7T9L, 6ZOY, 7K90, 7V87, 6VSB, 7E88, 6XKQ, 7R14, 7WED, 7P78, 7EJZ, 7WVP, 7KFX, 7L3N, 7Z1B, 7MTE, 7CZY, 7MJN, 7KN7, 7S5P, 7MZN, 7LWJ, 7B18, 7DZX, 7V7G, 7N9B, 7K8X, 7JZM, 7C8D, 7R6X, 7V83, 6ZH9, 7MJJ, 7E7B, 7CJF, 7N1E, 7DX7, 7A93, 7EU2, 7N6D, 6LZG, 6YOR, 7CZV, 7KMZ, 7VX1, 7RXD, 7R11, 6YLA, 7DQA, 7V7D, 7TF2, 7MZJ, 7ENF, 7V79, 7PQY, 7WD8, 7KRR, 7KDK, 7R1B, 7Q9J, 6ZP7, 7CHP, 7WUE, 7TP1, 7LRS, 7DPM, 7SBS, 7E5Y, 7RW2, 7EH5, 7W9E, 7L7F, 7KEB, 7V7O, 6XDG, 7DK7, 7EAZ, 7SN2, 7E3B, 7SY7, 7M6E, 7FDG, 7DEU, 7JX3, 7WPH, 7WLC, 7N6E, 7P3D, 7V85, 7BEI, 7TAS, 7N1F, 7R12, 7E7X, 7VX5, 7EB0, 7CAC, 7LXZ, 7ND9, 6ZHD, 7JZU, 7CZW, 6XEY, 7L2C, 7PRY, 7KLG, 7AKD, 7B14, 7WDF, 7TF4, 6ZB5, 7MZL, 7CN9, 7VNB, 7KRS, 7KDL, 7D0B, 7WD9, 7SXT, 7ENG, 7C2L, 7JJI, 7TP3, 7LRT, 7CM4, 7Q9K, 7V7Q, 7KL9, 7RZQ, 6ZLR, 7LCN, 7A94, 7CWM, 7W9I, 7E3C, 7M6F, 6XE1, 7SN3, 7R7N, 7KEC, 7L0N, 7L7K, 7DF3, 7RPV, 7KJ4, 7DX5, 7K8T, 7NX7, 7SY3, 7MJH, 7ND6, 7E9Q, 7NEG, 7THK, 7EAM, 7BH9, 7V80, 7LYM, 7N62, 7MZF, 7L5B, 7BNO, 7F62, 7LX5, 7WK9, 7VXK, 7K9Z, 7TEY, 7CHE, 7Q1Z, 7FG7, 7KMI, 7RBY, 7Q6E, 7E5R, 7VXF, 7FJO, 6W41, 7F4W, 7BZ5, 7TOX, 7SBP, 7Z1E, 7N1T, 7BEO, 7RNJ, 7M8S, 6ZFO, 7NKT, 7V7J, 7DK5, 7SOE, 7W99, 7MY3, 6XS6, 7R6W, 7THT, 7FCD, 7MMO, 7SY5, 7MJI, 7K8V, 7NX8, 7EFP, 7WKA, 7DX6, 7LWQ, 7V81, 7ORB, 6YZ7, 7MZH, 7F63, 7N64, 7N1V, 7TF0, 7N1A, 7LYN, 7FAF, 7V77, 7MSQ, 7EDJ, 7R1A, 7KRQ, 7CHH, 7N0G, 7N1U, 7SBQ, 7M8U, 7E5S, 7CZS, 7KMK, 7TOZ, 7KEA, 7JWB, 7E9T, 7V2A, 7L7E, 7OWX, 7DK6, 7SOF, 7LQW, 7W9B, 7MDW, 7P7A, 7LY3, 6ZP0, 7FG2, 7KMG, 7CDJ, 7MKL, 7VXC, 7TLD, 7WCZ, 7D30, 7L56, 7PS1, 7N9E, 7DK3, 7TOU, 7TE1, 7EDG, 7TPF, 7CH5, 7M7W, 7S5R, 7CYV, 7L2F, 7M71, 7DX2, 7E3L, 7R8O, 7RZU, 7TCC, 7LWL, 7RA8, 7SXY, 6M0J, 7TPC, 7Q0G, 6VYB, 7DK2, 7V7U, 7E8F, 7JV6, 7K9I, 6X2C, 7ND3, 6XC3, 7LWU, 7V8A, 7DD2, 6XM3, 7MW4, 7KMH, 7R18, 7M8K, 7P7B, 7CHC, 7MKM, 7BEN, 7VXE, 7E5O, 7BYR, 6ZP1, 7CZQ, 7WD0, 7TOW, 7M3I, 7NP1, 7L57, 7DK4, 7V7I, 7Q9F, 7PS2, 7F46, 7KNI, 7EDH, 7KDH, 7X7D, 6M1V, 7TPL, 7A5R, 7SY0, 7RZV, 7R95, 7Q0H, 7E3O, 7DX3, 7A4N, 6X45, 6XR8, 7E9N, 6M17, 7RKU, 7LYK, 7MEJ, 7BNM, 7ND4, 7K9J, 7M0J, 7K4N, 6XC4, 7K8M, 7JVB, 7MW6, 7V8C, 7LOP, 7BEJ, 7LY0, 7NDA, 7T9K, 7LWS, 7E86, 6XKP, 7R13, 7N3I, 7DCC, 6Z2M, 7C8W, 7VX9, 6ZBP, 7N1Q, 7L2D, 7SBK, 7KN6, 7PRZ, 7MTD, 7WBQ, 7MZM, 7TF5, 6VW1, 7N9A, 7AD1, 7KLW, 7SXV, 7N8H, 7W92, 7WBP, 7JJJ, 7VND, 7D0C, 7M6G, 7MTC, 7KN4, 7Q9M, 7RZR, 7TP7, 7SO9, 7JMO, 7CAI, 7A95, 7OAN, 7EB3, 7EYA, 7CWO, 7TB8, 7DF4, 7NXC, 7LD1, 7VXB, 7LY2, 7BEK, 7EK0, 7N4J, 7V88, 7B62, 7LWT, 6ZOZ, 7WCR, 7K9H, 7P79, 7N9C, 7KFY, 7PS0, 7SBL, 7CZZ, 7CYH, 7WVQ, 7S5Q, 7KM5, 7L2E, 7DZY, 7MKB, 7KNB, 7T01, 6ZCZ, 6Z43, 7W94, 7DX1, 6VXX, 7E3K, 7Q0A, 7SXW, 7D0D, 7TC9, 7NY5, 7EZV, 7S4S, 7FEM, 7TP9, 7Q9P, 6XF6, 7V7T, 7MW2, 7JV4, 6X2B, 7D2Z, 7OAO, 7CAK, 7DCX, 7CWT, 6XLU
Interactors (60)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9BYF1 ACE2  5 0.998 254
 UniProt:P0DTC2 S  20 0.986 60
 UniProt:Q9NNX6 CD209  1 0.888 12
 UniProt:Q9H2X3 CLC4M      0.857 12
 UniProt:P09958 FURIN  4 0.854 5
 UniProt:P11021 HSPA5  6 0.746 8
 UniProt:Q9C0B5 ZDHHC5  1 0.725 5
 UniProt:Q7Z5G4 GOLGA7  3 0.725 5
 UniProt:Q8R0I0  1 0.688 4
 UniProt:Q8IUN9-2 CLEC10A      0.683 4
 UniProt:P35247-PRO_0000017465 SFTPD      0.683 11
 UniProt:Q96D42 HAVCR1  1 0.667 7
 UniProt:Q96L92 SNX27      0.664 16
 UniProt:P30530 AXL  2 0.655 9
 UniProt:P35613 BSG  2 0.652 7
 IntAct:EBI-26657218 PEPTIDE      0.645 7
 ChEBI:17033 BILIVERDIN      0.642 9
 UniProt:Q58DD0 ACE2      0.641 3
 UniProt:O14786 NRP1  1 0.639 9
 UniProt:P11226-PRO_0000017401 MBL2      0.632 11
 ChEBI:28304 HEPARIN      0.623 5
 UniProt:Q96LC7 SIGLEC10  1 0.623 2
 UniProt:P07711 CTSL  8 0.623 3
 UniProt:Q8IUN9 CLEC10A  1 0.623 4
 maltose [ChEBI:17306]  2 0.623 3
 UniProt:P59665-PRO_0000006773 DEFA1      0.618 3
 UniProt:A5CKE2 A5CKE2      0.618 3
 UniProt:P31431 SDC4  20 0.599 17
 UniProt:P14635 CCNB1  4 0.59 2
 hemin [ChEBI:50385]  1 0.59 2
 IntAct:EBI-27090397 RC-101      0.558 2
 cholesterol [ChEBI:16113]  20 0.558 5
 N-acetylneuraminic acid [ChEBI:17012]  4 0.558 2
 UniProt:Q07021-PRO_0000018590 C1QBP      0.558 2
 UniProt:Q61830 Mrc1  4 0.558 2
 lipopolysaccharide [ChEBI:16412]  5 0.558 3
 UniProt:P35247 SFTPD  3 0.544 3
 UniProt:P01130 LDLR  4 0.537 4
 UniProt:P00533 EGFR  20 0.537 4
 IntAct:EBI-26657222 PEPTIDE      0.525 2
 IntAct:EBI-26657225 PEPTIDE      0.525 2
 IntAct:EBI-26997889 ACE2      0.524 2
 UniProt:A0A1S3APE5 A0A1S3APE5      0.524 2
 UniProt:E2DHI3 E2DHI3      0.524 2
 UniProt:Q14416 GRM2  1 0.524 4
 UniProt:P08670 VIM  11 0.524 4
 UniProt:Q5EGZ1  1 0.524 2
 linoleic acid [ChEBI:17351]  6 0.522 2
 UniProt:P35579 MYH9  3 0.518 7
 UniProt:P35606 COPB2  4 0.499 3
 UniProt:Q9Y5S1 TRPV2  1 0.499 2
 UniProt:Q5EA32  1 0.499 3
 UniProt:Q5MNZ6 WDR45B  1 0.499 4
 UniProt:Q15005 SPCS2  1 0.499 2
 UniProt:Q15436 SEC23A  4 0.499 20
 UniProt:P26038 MSN  4 0.499 20
 UniProt:P0DTD1-PRO_0000449625 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449627 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449628 REP      0.488 2
 UniProt:P15311 EZR  3 0.483 10
Cite Us!