S(686-815) [plasma membrane]

Stable Identifier
Protein [EntityWithAccessionedSequence]
Severe acute respiratory syndrome coronavirus 2
Locations in the PathwayBrowser

SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

External Reference Information
External Reference
Gene Names
S, 2
signal peptide:1-13, chain:14-1273, chain:14-685, chain:686-1273, chain:816-1273
Reference Transcript
Other forms of this molecule
Modified Residues
palmitoylated-L-cysteine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 709
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 717
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
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7CZW, 6XEY, 7L2C, 7PRY, 7KLG, 7AKD, 7B14, 7WDF, 7TF4, 6ZB5, 7MZL, 7CN9, 7VNB, 7KRS, 7KDL, 7D0B, 7WD9, 7SXT, 7ENG, 7C2L, 7JJI, 7TP3, 7LRT, 7CM4, 7Q9K, 7V7Q, 7KL9, 7RZQ, 6ZLR, 7LCN, 7A94, 7CWM, 7W9I, 7E3C, 7M6F, 6XE1, 7SN3, 7R7N, 7KEC, 7L0N, 7L7K, 7DF3, 7RPV, 7KJ4, 7DX5, 7K8T, 7NX7, 7SY3, 7MJH, 7ND6, 7E9Q, 7NEG, 7THK, 7EAM, 7BH9, 7V80, 7LYM, 7N62, 7MZF, 7L5B, 7BNO, 7F62, 7LX5, 7WK9, 7VXK, 7K9Z, 7TEY, 7CHE, 7Q1Z, 7FG7, 7KMI, 7RBY, 7Q6E, 7E5R, 7VXF, 7FJO, 6W41, 7F4W, 7BZ5, 7TOX, 7SBP, 7Z1E, 7N1T, 7BEO, 7RNJ, 7M8S, 6ZFO, 7NKT, 7V7J, 7DK5, 7SOE, 7W99, 7MY3, 6XS6, 7R6W, 7THT, 7FCD, 7MMO, 7SY5, 7MJI, 7K8V, 7NX8, 7EFP, 7WKA, 7DX6, 7LWQ, 7V81, 7ORB, 6YZ7, 7MZH, 7F63, 7N64, 7N1V, 7TF0, 7N1A, 7LYN, 7FAF, 7V77, 7MSQ, 7EDJ, 7R1A, 7KRQ, 7CHH, 7N0G, 7N1U, 7SBQ, 7M8U, 7E5S, 7CZS, 7KMK, 7TOZ, 7KEA, 7JWB, 7E9T, 7V2A, 7L7E, 7OWX, 7DK6, 7SOF, 7LQW, 7W9B, 7MDW, 7P7A, 7LY3, 6ZP0, 7FG2, 7KMG, 7CDJ, 7MKL, 7VXC, 7TLD, 7WCZ, 7D30, 7L56, 7PS1, 7N9E, 7DK3, 7TOU, 7TE1, 7EDG, 7TPF, 7CH5, 7M7W, 7S5R, 7CYV, 7L2F, 7M71, 7DX2, 7E3L, 7R8O, 7RZU, 7TCC, 7LWL, 7RA8, 7SXY, 6M0J, 7TPC, 7Q0G, 6VYB, 7DK2, 7V7U, 7E8F, 7JV6, 7K9I, 6X2C, 7ND3, 6XC3, 7LWU, 7V8A, 7DD2, 6XM3, 7MW4, 7KMH, 7R18, 7M8K, 7P7B, 7CHC, 7MKM, 7BEN, 7VXE, 7E5O, 7BYR, 6ZP1, 7CZQ, 7WD0, 7TOW, 7M3I, 7NP1, 7L57, 7DK4, 7V7I, 7Q9F, 7PS2, 7F46, 7KNI, 7EDH, 7KDH, 7X7D, 6M1V, 7TPL, 7A5R, 7SY0, 7RZV, 7R95, 7Q0H, 7E3O, 7DX3, 7A4N, 6X45, 6XR8, 7E9N, 6M17, 7RKU, 7LYK, 7MEJ, 7BNM, 7ND4, 7K9J, 7M0J, 7K4N, 6XC4, 7K8M, 7JVB, 7MW6, 7V8C, 7LOP, 7BEJ, 7LY0, 7NDA, 7T9K, 7LWS, 7E86, 6XKP, 7R13, 7N3I, 7DCC, 6Z2M, 7C8W, 7VX9, 6ZBP, 7N1Q, 7L2D, 7SBK, 7KN6, 7PRZ, 7MTD, 7WBQ, 7MZM, 7TF5, 6VW1, 7N9A, 7AD1, 7KLW, 7SXV, 7N8H, 7W92, 7WBP, 7JJJ, 7VND, 7D0C, 7M6G, 7MTC, 7KN4, 7Q9M, 7RZR, 7TP7, 7SO9, 7JMO, 7CAI, 7A95, 7OAN, 7EB3, 7EYA, 7CWO, 7TB8, 7DF4, 7NXC, 7LD1, 7VXB, 7LY2, 7BEK, 7EK0, 7N4J, 7V88, 7B62, 7LWT, 6ZOZ, 7WCR, 7K9H, 7P79, 7N9C, 7KFY, 7PS0, 7SBL, 7CZZ, 7CYH, 7WVQ, 7S5Q, 7KM5, 7L2E, 7DZY, 7MKB, 7KNB, 7T01, 6ZCZ, 6Z43, 7W94, 7DX1, 6VXX, 7E3K, 7Q0A, 7SXW, 7D0D, 7TC9, 7NY5, 7EZV, 7S4S, 7FEM, 7TP9, 7Q9P, 6XF6, 7V7T, 7MW2, 7JV4, 6X2B, 7D2Z, 7OAO, 7CAK, 7DCX, 7CWT, 6XLU
Interactors (60)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9BYF1 ACE2  5 0.998 254
 UniProt:P0DTC2 S  20 0.986 60
 UniProt:Q9NNX6 CD209  1 0.888 12
 UniProt:Q9H2X3 CLC4M      0.857 12
 UniProt:P09958 FURIN  4 0.854 5
 UniProt:P11021 HSPA5  6 0.746 8
 UniProt:Q9C0B5 ZDHHC5  1 0.725 5
 UniProt:Q7Z5G4 GOLGA7  3 0.725 5
 UniProt:Q8R0I0  1 0.688 4
 UniProt:Q8IUN9-2 CLEC10A      0.683 4
 UniProt:P35247-PRO_0000017465 SFTPD      0.683 11
 UniProt:Q96D42 HAVCR1  1 0.667 7
 UniProt:Q96L92 SNX27      0.664 16
 UniProt:P30530 AXL  2 0.655 9
 UniProt:P35613 BSG  2 0.652 7
 IntAct:EBI-26657218 PEPTIDE      0.645 7
 ChEBI:17033 BILIVERDIN      0.642 9
 UniProt:Q58DD0 ACE2      0.641 3
 UniProt:O14786 NRP1  1 0.639 9
 UniProt:P11226-PRO_0000017401 MBL2      0.632 11
 ChEBI:28304 HEPARIN      0.623 5
 UniProt:Q96LC7 SIGLEC10  1 0.623 2
 UniProt:P07711 CTSL  8 0.623 3
 UniProt:Q8IUN9 CLEC10A  1 0.623 4
 maltose [ChEBI:17306]  2 0.623 3
 UniProt:P59665-PRO_0000006773 DEFA1      0.618 3
 UniProt:A5CKE2 A5CKE2      0.618 3
 UniProt:P31431 SDC4  20 0.599 17
 UniProt:P14635 CCNB1  4 0.59 2
 hemin [ChEBI:50385]  1 0.59 2
 IntAct:EBI-27090397 RC-101      0.558 2
 cholesterol [ChEBI:16113]  20 0.558 5
 N-acetylneuraminic acid [ChEBI:17012]  4 0.558 2
 UniProt:Q07021-PRO_0000018590 C1QBP      0.558 2
 UniProt:Q61830 Mrc1  4 0.558 2
 lipopolysaccharide [ChEBI:16412]  5 0.558 3
 UniProt:P35247 SFTPD  3 0.544 3
 UniProt:P01130 LDLR  4 0.537 4
 UniProt:P00533 EGFR  20 0.537 4
 IntAct:EBI-26657222 PEPTIDE      0.525 2
 IntAct:EBI-26657225 PEPTIDE      0.525 2
 IntAct:EBI-26997889 ACE2      0.524 2
 UniProt:A0A1S3APE5 A0A1S3APE5      0.524 2
 UniProt:E2DHI3 E2DHI3      0.524 2
 UniProt:Q14416 GRM2  1 0.524 4
 UniProt:P08670 VIM  11 0.524 4
 UniProt:Q5EGZ1  1 0.524 2
 linoleic acid [ChEBI:17351]  6 0.522 2
 UniProt:P35579 MYH9  3 0.518 7
 UniProt:P35606 COPB2  4 0.499 3
 UniProt:Q9Y5S1 TRPV2  1 0.499 2
 UniProt:Q5EA32  1 0.499 3
 UniProt:Q5MNZ6 WDR45B  1 0.499 4
 UniProt:Q15005 SPCS2  1 0.499 2
 UniProt:Q15436 SEC23A  4 0.499 20
 UniProt:P26038 MSN  4 0.499 20
 UniProt:P0DTD1-PRO_0000449625 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449627 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449628 REP      0.488 2
 UniProt:P15311 EZR  3 0.483 10
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