Reactome | H2Av1 [nucleoplasm]

H2Av1 [nucleoplasm]

Stable Identifier

R-DDI-181887-3

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

H2AFB1, Q54HW2

Locations in the PathwayBrowser

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Cell Cycle (Dictyostelium discoideum)

- Cell Cycle, Mitotic (Dictyostelium discoideum)
  - M Phase (Dictyostelium discoideum)
    - Mitotic Prophase (Dictyostelium discoideum)
      - Condensation of Prophase Chromosomes (Dictyostelium discoideum)
        
        Condensin II complex binds H4K20me1-containing nucleosomes (Dictyostelium discoideum)
        
        Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        PHF8 demethylates histone H4K20me1 (Dictyostelium discoideum)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        PLK1 binds phosphorylated condensin II complex (Dictyostelium discoideum)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)
        
        Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)

Cellular responses to stimuli (Dictyostelium discoideum)

- Cellular responses to stress (Dictyostelium discoideum)
  - Cellular Senescence (Dictyostelium discoideum)
    - Oxidative Stress Induced Senescence (Dictyostelium discoideum)
      - KDM6B demethylates H3K27me3 on p16INK4A promoter (Dictyostelium discoideum)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        CDKN2A Gene:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)

DNA Replication (Dictyostelium discoideum)

- DNA Replication Pre-Initiation (Dictyostelium discoideum)
  - Assembly of the pre-replicative complex (Dictyostelium discoideum)
    - Assembly of the ORC complex at the origin of replication (Dictyostelium discoideum)
      - ORC1 binds to H4K20me2 (Dictyostelium discoideum)
        
        H4K20Me2-nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        ORC1:H4K20Me2-nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        H4K20Me2-nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)

Gene expression (Transcription) (Dictyostelium discoideum)

- Epigenetic regulation of gene expression (Dictyostelium discoideum)
  - Negative epigenetic regulation of rRNA expression (Dictyostelium discoideum)
    - SIRT1 negatively regulates rRNA expression (Dictyostelium discoideum)
      - eNoSC deacetylates histone H3 (Dictyostelium discoideum)
        
        Chromatin [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        Chromatin with acetylated H3 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome (H3K9ac, H3K14ac) [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        eNoSC [nucleoplasm] (Dictyostelium discoideum)
        
        Chromatin (H3K9me2) [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
      - eNoSC dimethylates histone H3 at lysine-9 (Dictyostelium discoideum)
        
        Chromatin (H3K9me2) [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        Chromatin [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        eNoSC [nucleoplasm] (Dictyostelium discoideum)
        
        Chromatin (H3K9me2) [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
- RNA Polymerase I Transcription (Dictyostelium discoideum)
  - RNA Polymerase I Promoter Clearance (Dictyostelium discoideum)
    - RNA Polymerase I Promoter Escape (Dictyostelium discoideum)
      - Elongation of pre-rRNA transcript (Dictyostelium discoideum)
        
        Chromatin (H3K9me2):CBX3 [nucleoplasm] (Dictyostelium discoideum)
        
        Chromatin (H3K9me2) [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)

Signal Transduction (Dictyostelium discoideum)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
  - Signaling by Rho GTPases (Dictyostelium discoideum)
    - RHO GTPase Effectors (Dictyostelium discoideum)
      - RHO GTPases activate PKNs (Dictyostelium discoideum)
        
        Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Dictyostelium discoideum)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Dictyostelium discoideum)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Dictyostelium discoideum)
        
        KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K9me3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Dictyostelium discoideum)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av1 [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54HW2

Gene Names

H2Av1

Reference Genes

BioGPS Gene:8627000 H2Av1

dictyBase:DDB_G0289187

ENSEMBL:DDB_G0289187

KEGG Gene (Dictyostelium discoideum):DDB_G0289187 H2Av1

Monarch:8627000 H2Av1

NCBI Gene:8627000 H2Av1

Reference Transcript

RefSeq:XM_631235.1 H2Av1

Participates

as a member of

Homologues of H2AFB1 [nucleoplasm] (Dictyostelium discoideum)

Other forms of this molecule

H2Av1 [nucleoplasm]

phospho-H2Av1 [nucleoplasm]

H2Av1 [nucleoplasm]

Inferred From

H2AFB1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_636327.1

PRO

Q54HW2

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